The importance of the 3'UTR in repressing ctgf gene expression was initially characacterised[1] and subsequently the minimal RNA element responsible for repression was identified[2] This element was predicted to form a stable secondary structure, which acts as a post-transcriptional cis-acting element of structure-anchored repression (CAESAR).
The 3'UTR of the ctgf/hcs24 gene in chicken has also been shown to be involved in repression of gene expression.[3]
^Kubota S, Kondo S, Eguchi T, et al. (2000). "Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: similarities to retroviral RNA-protein interactions". Oncogene. 19 (41): 4773–4786. doi:10.1038/sj.onc.1203835. PMID11032028.
^Mukudai Y, Kubota S, Takigawa M (2003). "Conserved repressive regulation of connective tissue growth factor/hypertrophic chondrocyte-specific gene 24 (ctgf/hcs24) enabled by different elements and factors among vertebrate species". Biol. Chem. 384 (1): 1–9. doi:10.1515/BC.2003.001. PMID12674494. S2CID25685816.
