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| ECHA InfoCard | 100.021.825  |
| Chemical and physical data | |
| Formula | C20H27NO |
| Molar mass | 297.442 g·mol−1 |
| 3D model (JSmol) | |
| Density | 1.19 g/cm3 |
| Melting point | 188 °C (370 °F) |
| Boiling point | 458.4 °C (857.1 °F) |
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Cyclorphan is an opioid analgesic of the morphinan family that was never marketed.[1] It acts as a μ-opioid receptor (MOR) weak partial agonistorantagonist, κ-opioid receptor (KOR) full agonist, and, to a much lesser extent, δ-opioid receptor (DOR) agonist (75-fold lower affinity relative to the KOR).[2][3] The drug was first synthesized in 1964 by scientists at Research Corporation.[4][5]: 232 Inclinical trials, it had relatively long duration, good absorption, and provided strong pain relief but produced psychotomimetic effects via KOR activation, so its development was not continued.[1][5]: 232, 237
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| Psychedelics (5-HT2A agonists) |
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| Deliriants (mAChR antagonists) |
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| μ-opioid (MOR) |
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| δ-opioid (DOR) |
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| κ-opioid (KOR) |
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| Nociceptin (NOP) |
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| Others |
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