Jump to content

Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

(Top) 1 Function 2 Interactions 3 References 4 Further reading

DYNLT3

●Español ●Татарча / tatarça ●Українська Edit links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version Appearance From Wikipedia, the free encyclopedia

DYNLT3

Identifiers

Aliases

DYNLT3, RP3, TCTE1L, TCTEX1L, dynein light chain Tctex-type 3

External IDs

OMIM: 300302; MGI: 1914367; HomoloGene: 21304; GeneCards: DYNLT3; OMA:DYNLT3 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xp11.4	Start	37,836,757 bp^[1]
Band	Xp11.4	End	37,847,571 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X\|X A1.1	Start	9,520,506 bp^[2]
Band	X\|X A1.1	End	9,529,242 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gums

gingival epithelium

pons

dorsal motor nucleus of vagus nerve

Pars compacta

Brodmann area 23

lateral nuclear group of thalamus

optic nerve

oral cavity

glomerulus

Top expressed in

Epithelium of choroid plexus

transitional epithelium of urinary bladder

seminal vesicula

deep cerebellar nuclei

medial vestibular nucleus

retinal pigment epithelium

lateral geniculate nucleus

epithelium of lens

conjunctival fornix

facial motor nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	cytoskeletal motor activity protein binding identical protein binding
Cellular component	cytoplasm kinetochore chromosome dynein complex cytoplasmic dynein complex microtubule chromosome, centromeric region cytoskeleton nucleus mitotic spindle astral microtubule
Biological process	cell cycle regulation of mitotic cell cycle cell division positive regulation of mitotic cell cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6990


67117

Ensembl


ENSG00000165169


ENSMUSG00000031176

UniProt


P51808


P56387

RefSeq (mRNA)


NM_006520


NM_025975

RefSeq (protein)


NP_006511


NP_080251

Location (UCSC)

Chr X: 37.84 – 37.85 Mb

Chr X: 9.52 – 9.53 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.^[5]^[6]

Function[edit]

DYNLT3 is a member of the dynein motor protein family. DYNLT3 binds to BUB3, a spindle checkpoint protein is present on kinetochoresatprometaphase.^[7] DYNLT3 can also function as a transcription regulator of Bcl-2 gene through binding to SATB1 in a dynein-independent manner.^[8]

Interactions[edit]

DYNLT3 has been shown to interact with VDAC1.^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165169 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031176 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: DYNLT3 dynein, light chain, Tctex-type 3".

^ Roux AF, Rommens J, McDowell C, Anson-Cartwright L, Bell S, Schappert K, Fishman GA, Musarella M (February 1994). "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex". Hum. Mol. Genet. 3 (2): 257–63. doi:10.1093/hmg/3.2.257. PMID 8004092.

^ Lo KW, Kogoy JM, Pfister KK (April 2007). "The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3". J. Biol. Chem. 282 (15): 11205–12. doi:10.1074/jbc.M611279200. PMID 17289665.

^ Yeh TY, Chuang JZ, Sung CH (August 2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286.

^ Schwarzer, Christian; Barnikol-Watanabe Shitsu; Thinnes Friedrich P; Hilschmann Norbert (Sep 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. ISSN 1357-2725. PMID 12009301. S2CID 11632830.

Further reading[edit]

Roux AF, Rommens J, McDowell C, et al. (1994). "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex". Hum. Mol. Genet. 3 (2): 257–63. doi:10.1093/hmg/3.2.257. PMID 8004092.

Bauch A, Campbell KS, Reth M (1998). "Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta". Eur. J. Immunol. 28 (7): 2167–77. doi:10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L. PMID 9692886. S2CID 21656634.

Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis". J. Biol. Chem. 277 (10): 7897–904. doi:10.1074/jbc.M111937200. PMID 11751937.

Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. PMID 12009301. S2CID 11632830.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Yeh TY, Chuang JZ, Sung CH (2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

O'Rourke SM, Dorfman MD, Carter JC, Bowerman B (2007). "Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants". PLOS Genet. 3 (8): e128. doi:10.1371/journal.pgen.0030128. PMC 1937013. PMID 17676955.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=DYNLT3&oldid=1188051031" Categories: ●Genes on human chromosome X ●Human chromosome X gene stubs Hidden categories: ●Articles with short description ●Short description is different from Wikidata ●All stub articles ●This page was last edited on 3 December 2023, at 01:52 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view