Biondini was transferred to Serie B team Vicenza Calcio in temporary deal in 2003. in 2004 the Veneto club acquired Biondini in co-ownership deal for €250,000.[1] In June 2005 Vicenza acquired Biondini outright after winning the bid mediated by Lega Calcio for €202,500.[nb 1]
In August 2005 Biondini was signed by Serie A club Reggina Calcio in another co-ownership deal for €500,000, which the Calabria team also signed Luca Rigoni from Veneto, with Ricardo Esteves moved to opposite direction. Biondini made his Serie A debut in 2005–06 Serie A. Circa January 2006 Reggina signed Biondini outright for another €700,000[nb 2], with Simone Cavalli moved to opposite direction outright for €775,000.[1]
On 11 January 2012, he left for Genoa on free transfer in 4+1⁄2-year contract.[4][5][nb 3] (However the transfer also cost Genoa €500,000 as other fee.[5])
After a single season, signed a loan deal with the newly promoted Serie A club Atalanta on 24 August 2012 for €200,000.[5][7][8][9]
On 23 January 2014, Biondini left for Sassuolo in a temporary deal for €200,000,[10] with an option to purchase,[11] re-joining Genoa teammate Antonio Floro Flores (loan) and Thomas Manfredini (definitive). In June 2014 Sassuolo excised the options to purchase Biondini and Floro Flores from Genoa, for €1.3 million[10] and €2.5 million respectively.[10]
In July 2018, he returned to the city where he started his professional career, joining Cesena.[12] Following Cesena's promotion back to Serie C at the end of the 2018–19 season, he retired from playing.[13]
With the Italy U-21 squad he took part at the 2006 Euro U-21 Championship. He wore the prestigious number 10 shirt, but just made one appearance as a substitute in the last match of the group stage.
Biondini made his senior national team debut on 14 November 2009 during a friendly match against the Netherlands.
^As co-ownership income of €47,500 for the discount.[1]
^As co-ownership income of €200,000 plus pre-agreed €500,000.[1]
^Cagliari did not disclosed the transfer detail in its financial report, however Biondini's residual contract value circa January 2012 was €38,321, and in the whole 2011–12 financial season Cagliari had a player trading loss (Italian: minusvalenze cessione calciatori) of €38,607.[6]
