In 2004, after having occupied different premises in Lausanne, Debiopharm moved its headquarters to a new building: what became『Après-demain Forum』had been initially designed by architect Jean Tschumi as the headquarters commodity trading giant Andre and is a cultural property of national significance.[11]
In 2005, Debiopharm acquired the Canadian company H3 Pharma, rebranded Debiovision, to support the development and worldwide registration of its medicines.[12]
The company's business model relies on establishing partnerships and research agreements with other companies or universities to develop new molecules and run clinical trials before licensing them in case of success. It partnered for instance in 2009 with US-based MSM Protein Technologies to work on a new oncology treatment,[13] in 2011 with Yale University as part of an agreement to develop and commercialise medicine for autoimmune and inflammatory diseases,[14] in 2014 with German company Evotec to identify and develop compounds to treat a variety of cancers,[15] or with Canadian company Nobelex Biotech (also in 2014) to develop antibiotics targeting Neisseria gonorrhoeae and enteric species.[16]
In March 2021, Merck KGaA announced the acquisition of Debiopharm's xevinapant program in head and neck cancer for 900 million euros.[17]
Debiopharm is the Life Science division of the holding company Après-demain (litt. "The Day after Tomorrow") with three subsidiaries active in drug development (Debiopharm International), drug manufacturing (Debiopharm Research & Manufacturing) and investment (Debiopharm Innovation Fund):[18][19]
Debiopharm International in-licenses product candidates or technologies, develops them into medicines, and then licenses them to third parties for commercialization.[20] This subsidiary is mainly focused on the development of medicines in the fields of oncology and infectious diseases, from preclinical development to full approval of new treatments.
Debiopharm Research & Manufacturing (formerly known as Debio R.P.),[3] based in Martigny, Switzerland, is a pharmaceutical research, development and production company.[4] The Swissmedic-ceritified production site was renovated and expanded in 2015.[21][22] Debiopharm Research & Manufacturing provides contract manufacturing and contract research services to Debiopharm.[10]
Debiopharm Innovation Fund provides venture capital for Digital Health companies.[23] The Fund notably invested in Carevive (US-based oncology-focused technology company) in 2020,[24] VivoSense (medical technology) in 2022[25] and Iktos (artificial intelligence applied to new drug discoveries) in 2023.[26] It also successfully exited Finnish oncology startup Kaiku Health, which was bought in 2020 by Swedish giant Elekta.[27]
Until 2020, the subsidiary Debiopharm Investment SA managed the group's asset management activities.[28] This subsidiary was merged and its former activities are now directly taken over by the holding company Après-demain SA.[28]
triptorelin is a gonadotropin-releasing hormone agonist (GnRH agonist) approved for several indications, including prostate cancer and endometriosis, under the names Decapeptyl, Neo Decapeptyl, Trelstar and Pamorelin.[6][7] This molecule is also marketed in several European countries as Salvacyl and Moapar as a three-month treatment for sexual deviance.[31]
Early-stage treatments being developed by Debiopharm are referred to by code names such as "Debio [+4 digit number]".[33] In 2020, Debiopharm signed a global license and research agreement with German biotech 3B Pharmaceuticals (3BP) to work on "Debio 0228", a treatment targeting the CAIX (Carbonic anhydrase 9) enzyme to fight the progression of cancer.[34] Other drug candidates under development include:
Xevinapant is a potent, orally available inhibitor of apoptosis proteins.[35] xevinapant has proven to be efficient in high-risk patients with locally advanced squamous-cell carcinomaof the head and neck (LASCCHN), where the combination provided a highly significant and durable clinical benefit.[35] Clinical research: phase III.[35] In March 2021, an exclusive license agreement has been granted to Merck KGaA for 900 million euros for further development and commercialisation of xevinapant.[36]
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Switzerland
