After graduating from college, Bryant began working at Intel in 1985.[2] In her final role at Intel, she led the data center group. In this role she helped the company to become a significant supplier of chips to corporate clients such as Amazon AWS, when previously Intel had primarily sold chips directly to consumers.[3] Before leading the data center group, Bryant was the chief information officer of Intel.[4]
In May 2017, she left her role at Intel in what was described as a temporary departure. However, on November 30, 2017, Google announced that Bryant would be joining Google Cloudaschief operating officer, and Intel announced her retirement effective December 1, 2017.[5] In July 2018, Google announced that she had left the company.[6]
Bryant was named among Fortune’s 50 Most Powerful Women in Business in 2015 and 2016.[8][9] Also in 2016, World Affairs honored Bryant as a part of its Global Philanthropy Forum.[10]Business Insider ranked Bryant #32 in their 2016 list of "Silicon Valley 100"[11] and she was #6 in their 2018 list of the "most powerful female engineers".[12]
On January 14, 2019, Bryant was named member of the board of Broadcom Inc.[13]
Bryant has served as the chairman and chief executive officer of NovaSignal Corporation from January 2020 to June 2023.[14]