Dobrava-Belgrade orthohantavirus (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-senseRNA virus species of Old World Orthohantavirus. It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated in 1985 from a yellow-necked mouse (Apodemus flavicollis) found in the village of Dobrava, southeastern Slovenia.[3][4] It was subsequently isolated in striped field mice in Russia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown.[5]
Clinical presentation varies between the four genotypes. Dobrava is the most virulent, with a case-fatality rate (CFR) of 10 to 12%, followed by Sochi, which has a CFR greater than 6%, then Kurkino, which has a CFR 0.3% to 0.9%, and lastly Saaremaa, which seems to mainly be subclinical as illness has not been reported despite a relatively high rate of seropositivity.[6]
^Avsic-Zupanc T, Xiao SY, Stojanovic R, Gligic A, van der Groen G, LeDuc JW (Oct 1992). "Characterization of Dobrava virus: a Hantavirus from Slovenia, Yugoslavia". J Med Virol. 38 (2): 132–7. doi:10.1002/jmv.1890380211. PMID1360999. S2CID30221111.
^Likar, Miha (1995). "Mišja mrzlica in virus Dobrava v Sloveniji" [Hemorrhagic Fever and the Dobrava Virus in Slovenia] (PDF). UJMA (in Slovenian) (11): 155–160. Archived from the original(PDF) on 2021-06-24. Retrieved 2021-06-21.
