On December 5, 2014, the Tigers traded Leyba and Robbie Ray to the Arizona Diamondbacks as part of a three-team trade, with the Diamondbacks sending Didi Gregorius to the New York Yankees and the Yankees sending Shane Greene to the Tigers.[4] He spent 2015 with the Visalia Rawhide where he batted .237 with two home runs and 43 RBIs in 124 games and 2016 with Visalia and the Mobile BayBears where he slashed .296/.355/.429 with ten home runs and 60 RBIs in 130 games.
The Diamondbacks added him to their 40-man roster after the 2016 season.[5] In 2017, he played in only 23 games due to injury.[6] He spent all of 2018 with the Jackson Generals, batting .269 with five home runs and 30 RBIs in 86 games.[7] He began 2019 with the Reno Aces.[8]
On June 22, 2019, he was called up to the major leagues for the first time.[9] He made his debut that night, recording a pinch-hit single off of Mark Melancon of the San Francisco Giants.[10] Leyba played in 21 major league games in 2019, mainly as a pinch hitter and defensive replacement. He collected a total of seven hits, including two doubles and a triple, batting.280.
On March 6, 2020, Leyba was suspended for the first 80 games of the 2020 season for testing positive for boldenone.[11] Due to Major League Baseball shortening the season to 60 games because of the COVID-19 pandemic, Leyba was essentially ruled out for the entire year. On November 20, 2020, Leyba was outrighted off of the 40-man roster following the waiver claim of Rogelio Armenteros.[12]
On May 15, 2021, Leyba was selected to the 40-man roster.[13] He was designated for assignment on June 2 after going hitless in 24 plate appearances across 13 games for Arizona.[14]
On June 4, 2021, Leyba was claimed off waivers by the Baltimore Orioles.[15]
Leyba hit his first career home run on July 2 on the road against Griffin Canning of the Los Angeles Angels.
On August 4, Leyba was designated for assignment by the Orioles.[16] On August 8, Leyba cleared waivers and was assigned outright to the Triple-A Norfolk Tides.[17] On August 19, Leyba was released by the Orioles.[18]
On September 3, 2021, Leyba signed a minor league deal with the Texas Rangers and was assigned to the Triple-A Round Rock Express.[19] Leyba played in 24 games for Round Rock, hitting .288 with 4 home runs and 26 RBI's. Leyba became a free agent following the season.
On December 14, 2021, Leyba signed with the San Diego Padres.[20] Leyba spent the majority of the 2022 season (98 games) with the Double-A San Antonio Missions, also playing in 10 games for the Triple-A El Paso Chihuahuas. Between the two affiliates, he posted a .255/.356/.399 slash with 11 home runs, 64 RBI, and 12 stolen bases. He elected free agency following the season on November 10, 2022.[21]
On March 3, 2023, Leyba signed a minor league contract with the Pittsburgh Pirates organization.[22] He split the season between the Double–A Altoona Curve and Triple–A Indianapolis Indians, playing in 72 total games and hitting .293/.371/.443 with 8 home runs and 35 RBI. Leyba elected free agency following the season on November 6.[23]
