Clinical data
Other names
Dotarizine
Identifiers
1-[diphenylmethyl]-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
C29H34N2O2
442.603 g·mol−1
3D model (JSmol)
C1CN(CCN1CCCC2(OCCO2)C3=CC=CC=C3)C(C4=CC=CC=C4)C5=CC=CC=C5
InChI=1S/C29H34N2O2/c1-4-11-25(12-5-1)28(26-13-6-2-7-14-26)31-21-19-30(20-22-31)18-10-17-29(32-23-24-33-29)27-15-8-3-9-16-27/h1-9,11-16,28H,10,17-24H2 N
Key:LRMJAFKKJLRDLE-UHFFFAOYSA-N N
Dotarizine is a drug used in the treatment of migraine,[1] which acts as a calcium channel blocker,[2] and also as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A and 5HT2C receptors.[3][4] The anti-migraine action is thought to be due to its action as a vasodilator,[5][6] but it also has some anxiolytic effects[7] and blocks amnesia produced by electroconvulsive shock in animals.[8]
Others
Others
IRKsTooltip Inwardly rectifying potassium channel
KCaTooltip Calcium-activated potassium channel
K2PsTooltip Tandem pore domain potassium channel
VGSCsTooltip Voltage-gated sodium channels
ENaCTooltip Epithelial sodium channel
ASICsTooltip Acid-sensing ion channel
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Unsorted
Others
LGICsTooltip Ligand gated ion channels
Simple piperazines
(no additional rings)
Diphenylalkylpiperazines
(benzhydrylalkylpiperazines)
Tricyclics
(piperazine attached via side chain)
Others/Uncategorized