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Sir Douglass Matthew Turnbull FRS FMedSci is Professor of Neurology at Newcastle University , an Honorary Consultant Neurologist at Newcastle upon Tyne Hospitals NHS Foundation Trust [1] and a director of the Wellcome Trust Centre for Mitochondrial Research .[2] [3] [4] [5]
Education [ edit ]
Turnbull was educated at Newcastle University , where he was awarded a Bachelor of Medicine, Bachelor of Surgery and qualifying as a junior doctor .[when? ] [2] He was subsequently awarded a PhD for research investigating Mitochondrial cytopathies.[6]
Research [ edit ]
Turnbull's research investigates techniques for improving the lives of patients with mitochondrial disease .[7] As of 2016[update] he has supervised 35 successful PhD students to completion and is currently supervising 10 PhD students in progress.[2] His most highly cited research[8] has been published in world leading peer reviewed scientific journals such as Nature ,[3] Nature Genetics ,[9] [10] Nature Reviews Genetics ,[11] the American Journal of Human Genetics ,[12] and the Journal of Clinical Investigation .[13]
His research has been funded by the Wellcome Trust , the Biotechnology and Biological Sciences Research Council (BBSRC) and the Medical Research Council (MRC) .[14]
Awards and honours [ edit ]
Turnbull delivered the Goulstonian Lectures in 1992 and was awarded the Jean Hunter Prize in 2003, both by the Royal College of Physicians .[2] He was elected a Fellow of the Academy of Medical Sciences in 2004.[15]
Turnbull was knighted in the 2016 Birthday Honours .[16] According to the BBC, his knighthood was awarded for "creating a groundbreaking IVF technique which prevents disabling genetic disorders from being passed on to future generations".[17] This technique uses mitochondrial donation , also known as "three-person babies".[18] [19]
Turnbull was awarded the Buchanan Medal for outstanding contributions to biomedicine particularly in relation to mitochondrial disease, including the development of a method to prevent their transmission.[20]
References [ edit ]
^ a b Craven, Lyndsey; Tuppen, Helen A.; Greggains, Gareth D.; Harbottle, Stephen J.; Murphy, Julie L.; Cree, Lynsey M.; Murdoch, Alison P.; Chinnery, Patrick F.; Taylor, Robert W.; Lightowlers, Robert N.; Herbert, Mary; Turnbull, Douglass M. (2010). "Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease" . Nature . 465 (7294): 82–85. Bibcode :2010Natur.465...82C . doi :10.1038/nature08958 . PMC 2875160 . PMID 20393463 .
^ Healing broken batteries: The Wellcome Trust Centre for Mitochondrial Research on YouTube , Wellcome Trust , London
^ Graeme Whitfield (2015). "Newcastle University medical pioneer Doug Turnbull discusses his game-changing research" . thejournal.co.uk . Newcastle: The Journal . Archived from the original on 2020-08-18. Retrieved 2016-06-16 .
^ Turnbull, Douglass Matthew (1983). Mitochondrial cytopathies: clinical and experimental studies (PhD thesis). Newcastle upon Tyne University. OCLC 11274373 .
^ Lightowlers, Robert N.; Chinnery, Patrick F.; Turnbull, Douglass M.; Howell, Neil (1997). "Mammalian mitochondrial genetics: heredity, heteroplasmy and disease". Trends in Genetics . 13 (11 ): 450–455. doi :10.1016/S0168-9525(97 )01266-3 . PMID 9385842 .
^ Douglass Turnbull's publications indexed by the Scopus bibliographic database. (subscription required)
^ Turnbull, Douglass M.; Andrews, Richard M.; Kubacka, Iwona; Chinnery, Patrick F.; Lightowlers, Robert N.; Howell, Neil (1999). "Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA" . Nature Genetics . 23 (2 ): 147. doi :10.1038/13779 . PMID 10508508 .
^ Bender, Andreas; Krishnan, Kim J; Morris, Christopher M; Taylor, Geoffrey A; Reeve, Amy K; Perry, Robert H; Jaros, Evelyn; Hersheson, Joshua S; Betts, Joanne; Klopstock, Thomas; Taylor, Robert W; Turnbull, Douglass M (2006). "High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease". Nature Genetics . 38 (5 ): 515–517. doi :10.1038/ng1769 . PMID 16604074 . S2CID 13956928 .
^ Taylor, Robert W.; Turnbull, Doug M. (2005). "Mitochondrial DNA mutations in human disease" . Nature Reviews Genetics . 6 (5 ): 389–402. doi :10.1038/nrg1606 . PMC 1762815 . PMID 15861210 .
^ Herrnstadt, Corinna; Elson, Joanna L.; Fahy, Eoin; Preston, Gwen; Turnbull, Douglass M.; Anderson, Christen; Ghosh, Soumitra S.; Olefsky, Jerrold M.; Beal, M. Flint; Davis, Robert E.; Howell, Neil (2002). "Reduced-Median-Network Analysis of Complete Mitochondrial DNA Coding-Region Sequences for the Major African, Asian, and European Haplogroups" . The American Journal of Human Genetics . 70 (5 ): 1152–1171. doi :10.1086/339933 . PMC 447592 . PMID 11938495 .
^ Taylor, Robert W.; Barron, Martin J.; Borthwick, Gillian M.; Gospel, Amy; Chinnery, Patrick F.; Samuels, David C.; Taylor, Geoffrey A.; Plusa, Stefan M.; Needham, Stephanie J.; Greaves, Laura C.; Kirkwood, Thomas B.L.; Turnbull, Douglass M. (2003). "Mitochondrial DNA mutations in human colonic crypt stem cells" . Journal of Clinical Investigation . 112 (9 ): 1351–1360. doi :10.1172/JCI19435 . PMC 228466 . PMID 14597761 .
^ "UK Government grants awarded to Doug Turnbull" . rcuk.ac.uk . Swindon: Research Councils UK . Archived from the original on 2016-06-16.
^ "Professor Doug Turnbull FMedSci" . acmedsci.ac.uk . London: Academy of Medical Sciences . Archived from the original on 2016-06-16.
^ "No. 61608" . The London Gazette (Supplement). 2016-06-11. p. B2.
^ Anon (2016). "Birthday honours: Mitochondrial disease doctor recognised" . bbc.co.uk . London: BBC News .
^ Mark Henderson (2015). "Three-person embryos: how the mitochondrial donation battle was won. Prof Doug Turnbull successfully communicated difficult and controversial research with scientific accuracy, but in simple terms" . The Guardian . London. Archived from the original on 2016-02-05.
^ James Gallagher (2015). "Three-person babies - not three-parent babies" . bbc.co.uk . London: BBC News . Archived from the original on 2016-03-02.
^ "Buchanan Medallist 2020" . Royal Society. Archived from the original on 23 October 2019. Retrieved 18 August 2020 .
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Douglass_Turnbull&oldid=1206519039 "
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