Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.[5][6][7][8]
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins.[6]
Patients with mutations in this gene develop Wolcott-Rallison syndrome.[9]
EIF2AK3 has been shown to interact with DNAJC3,[10] NFE2L2,[11] and endoplasmic reticulum chaperone BiP (Hsp70).[12]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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