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F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Efungumab (trade name Mycograb ) was a drug developed by NeuTec Pharma (a subsidiary of Novartis ), intended to treat candidemia (a bloodstream infection caused by pathogenic yeast ) in combination with amphotericin B . The European Medicines Agency has twice refused to grant marketing authorization for Mycograb, citing product safety and quality issues.[1]
Chemically, efungumab is a single-chain variable fragment of a human monoclonal antibody .[2]
Its ability to potentiate the effects of the antifungal amphotericin B in culture were later found to be non-specific.[3]
References
[ edit ]
^ Richie DL, Ghannoum MA, Isham N, Thompson KV, Ryder NS (2012). "Nonspecific effect of Mycograb on amphotericin B MIC" . Antimicrob. Agents Chemother . 56 7 ): 3963–4. doi :10.1128/AAC.00435-12 . PMC 3393390 PMID 22508314 .
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Efungumab&oldid=1190950584 " C a t e g o r i e s : ● D r u g s n o t a s s i g n e d a n A T C c o d e ● D r u g s d e v e l o p e d b y N o v a r t i s ● A b a n d o n e d d r u g s ● A n t i i n f e c t i v e a g e n t s t u b s ● M o n o c l o n a l a n t i b o d y s t u b s H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a ● C h e m i c a l s t h a t d o n o t h a v e a C h e m S p i d e r I D a s s i g n e d ● I n f o b o x - d r u g m o l e c u l a r - w e i g h t u n e x p e c t e d - c h a r a c t e r ● A r t i c l e s w i t h o u t E B I s o u r c e ● C h e m i c a l p a g e s w i t h o u t D r u g B a n k i d e n t i f i e r ● A r t i c l e s w i t h o u t I n C h I s o u r c e ● D r u g s w i t h n o l e g a l s t a t u s ● D r u g b o x e s w h i c h c o n t a i n c h a n g e s t o v e r i f i e d f i e l d s ● D r u g b o x e s w h i c h c o n t a i n c h a n g e s t o w a t c h e d f i e l d s ● D r u g s t h a t a r e a m o n o c l o n a l a n t i b o d y ● A l l s t u b a r t i c l e s
● T h i s p a g e w a s l a s t e d i t e d o n 2 0 D e c e m b e r 2 0 2 3 , a t 2 0 : 0 5 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
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