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1 References  













Esuprone






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From Wikipedia, the free encyclopedia
  

Esuprone

Names

Preferred IUPAC name

3,4-Dimethyl-2-oxo-2H-1-benzopyran-7-yl ethanesulfonate

Identifiers

CAS Number

3D model (JSmol)

ChEMBL

ChemSpider

PubChem CID

UNII

CompTox Dashboard (EPA)

  • InChI=1S/C13H14O5S/c1-4-19(15,16)18-10-5-6-11-8(2)9(3)13(14)17-12(11)7-10/h5-7H,4H2,1-3H3 checkY

    Key: CHDGAVDQRSPBTA-UHFFFAOYSA-N checkY

  • InChI=1/C13H14O5S/c1-4-19(15,16)18-10-5-6-11-8(2)9(3)13(14)17-12(11)7-10/h5-7H,4H2,1-3H3

    Key: CHDGAVDQRSPBTA-UHFFFAOYAR

    • O=S(=O)(Oc2ccc\1c(OC(=O)/C(=C/1C)C)c2)CC

    Properties[1]

    Chemical formula

    C13H14O5S

    Molar mass

    282.31 g·mol−1

    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    ☒N verify (what is checkY☒N ?)

    Infobox references

    Esuprone is an experimental drug candidate being investigated as an antidepressant.[2] It acts as a monoamine oxidase A (MAO-A) inhibitor.[3]

    References[edit]

    1. ^ Ganellin, C. R (1996). Dictionary of pharmacological agents. CRC Press. p. 1056. ISBN 978-0-412-46630-4.
  • ^ Vértes, Attila (2003). Handbook of nuclear chemistry. Springer. p. 155. ISBN 978-1-4020-1316-4.
  • ^ Bergström, M; Westerberg, G; Németh, G; Traut, M; Gross, G; Greger, G; Müller-Peltzer, H; Safer, A; et al. (1997). "MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: In vivo studies with positron emission tomography". European Journal of Clinical Pharmacology. 52 (2): 121–8. doi:10.1007/s002280050260. PMID 9174681. S2CID 25359613.

    • Non-specific

    AAADTooltip Aromatic L-amino acid decarboxylase

  • 5-HTP→Serotonin
  • L-Histidine→Histamine
  • Phenylalanine→Phenethylamine
  • L-Tyrosine→Tyramine
  • Tryptophan→Tryptamine

    • MAOTooltip Monoamine oxidase

  • Metanephrine→MHPG/VMA
  • Norepinephrine (noradrenaline)→DHMA
  • Normetanephrine→MHPG/VMA
  • Dopamine→DOPAC
  • 3-Methoxytyramine→HVA
  • Serotonin→5-HIAA

  • Bazinaprine
  • Befloxatone
  • Brofaromine
  • Cimoxatone
  • Clorgiline
  • CX157 (Tyrima)
  • Eprobemide
  • Esuprone
  • Harmala alkaloids (e.g., harmine, harmaline, harman, norharman, tetrahydroharmine)
  • Methylene blue
  • Metralindole
  • Minaprine
  • Moclobemide
  • Pirlindole
  • Sercloremine
  • Tetrindole
  • Toloxatone

  • Almoxatone
  • D-Deprenyl
  • Ethanol
  • Ladostigil
  • Lazabemide
  • Milacemide
  • Mofegiline
  • Nicotine
  • Pargyline‡
  • Rasagiline
  • Safinamide
  • Selegiline (L-Deprenyl)
  • Sembragiline

    • Phenethylamines
    (dopamine, epinephrine,
    norepinephrine)

    PAHTooltip Phenylalanine hydroxylase

    THTooltip Tyrosine hydroxylase

    DBHTooltip Dopamine beta-monooxygenase

    PNMTTooltip Phenylethanolamine N-methyltransferase

    COMTTooltip Catechol-O-methyl transferase

  • DOPAC→Homovanillic acid
  • Norepinephrine→Normetanephrine
  • Epinephrine→Metanephrine
  • DOPEG→MOPEG
  • DOMA→VMA
  • 2-Hydroxyestradiol→2-Methoxyestradiol
  • 2-Hydroxyestrone→2-Methoxyestrone
  • 4-Hydroxyestradiol→4-Methoxyestradiol
  • 4-Hydroxyestrone→4-Methoxyestrone

    • Tryptamines
    (serotonin, melatonin)

    TPHTooltip Tryptophan hydroxylase

  • Fenclonine (PCPA)
  • Telotristat ethyl

    • AANATTooltip Serotonin N-acetyl transferase

    ASMTTooltip Acetylserotonin O-methyltransferase

    Histamine

    HDCTooltip Histidine decarboxylase

  • Alpha-Fluoromethylhistidine
  • Histidine methyl ester
  • Meciadanol
  • Naringenin
  • Tritoqualine

    • HNMTTooltip Histamine N-methyltransferase

    DAOTooltip Diamine oxidase

    See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins


    Retrieved from "https://en.wikipedia.org/w/index.php?title=Esuprone&oldid=1124560712"
    Categories: 
    ●Antidepressants
     ●Phenyl sulfonate ethers
     ●Coumarins
     Hidden categories: 
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    ●This page was last edited on 29 November 2022, at 09:43 (UTC).
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