Exotoxin A | |||||||
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Identifiers | |||||||
Organism | Pseudomonas aeruginosa | ||||||
Symbol | eta | ||||||
UniProt | P11439 | ||||||
Other data | |||||||
EC number | 2.4.2.36 | ||||||
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The Pseudomonas exotoxin (orexotoxin A) is an exotoxin produced by Pseudomonas aeruginosa.[1] Vibrio cholerae produces a similar protein called the Cholix toxin (Q5EK40).[2]
It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of diphtheria toxin.[3]
It has been investigated as a treatment for hepatitis B[4] and cancer.[5]