Contents

F2RL3

Protein-coding gene in the species Homo sapiens

F2RL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZPK, 3QDZ
Identifiers
Aliases	F2RL3, PAR4, F2R like thrombin/trypsin receptor 3, F2R like thrombin or trypsin receptor 3
External IDs	OMIM: 602779; MGI: 1298207; HomoloGene: 36148; GeneCards: F2RL3; OMA:F2RL3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 16,888,999 bp[1] End 16,892,606 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 35.08 cM|8 B3.3 Start 73,488,508 bp[2] End 73,490,502 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung left lobe of thyroid gland subcutaneous adipose tissue islet of Langerhans right lobe of thyroid gland lactiferous gland monocyte body of stomach transverse colon Top expressed in left lobe of liver right lobe of liver vasculature vasculature of organ choroid plexus embryo spleen yolk sac quadriceps femoris muscle placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thrombin-activated receptor activity signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane extracellular region integral component of plasma membrane membrane plasma membrane Biological process platelet activation hemostasis phospholipase C-activating G protein-coupled receptor signaling pathway thrombin-activated receptor signaling pathway positive regulation of release of sequestered calcium ion into cytosol platelet dense granule organization response to wounding signal transduction blood coagulation positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9002 14065 Ensembl ENSG00000127533 ENSMUSG00000050147 UniProt Q96RI0 O88634 RefSeq (mRNA) NM_003950 NM_007975 RefSeq (protein) NP_003941 NP_032001 Location (UCSC) Chr 19: 16.89 – 16.89 Mb Chr 8: 73.49 – 73.49 Mb PubMed search [3] [4]
Wikidata
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Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.^[5]

Function[edit]

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.^[5]

See also[edit]

• Protease-activated receptor

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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