FABP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | FABP2, FABPI, I-FABP, fatty acid binding protein 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 134640; MGI: 95478; HomoloGene: 107; GeneCards: FABP2; OMA:FABP2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Fatty acid-binding protein 2 (FABP2), also known as Intestinal-type fatty acid-binding protein (I-FABP), is a protein that in humans is encoded by the FABP2 gene.[5]
The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells.[5]
This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.[5]
PDB gallery
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1kzw: Solution structure of Human Intestinal Fatty acid binding protein
1kzx: Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T)
3ifb: NMR STUDY OF HUMAN INTESTINAL FATTY ACID BINDING PROTEIN
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Fatty acid |
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Hormone |
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Metal/element |
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Vitamin |
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