Contents

FER (gene)

Protein-coding gene in the species Homo sapiens

FER
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KK6
Identifiers
Aliases	FER, FerT, PPP1R74, Pe1Fe10, Pe1Fe13, Pe1Fe3, Pe1Fe6, TYK3, p94-Fer, FER tyrosine kinase
External IDs	OMIM: 176942; MGI: 105917; HomoloGene: 74300; GeneCards: FER; OMA:FER - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q21.3 Start 108,747,841 bp[1] End 109,196,841 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E1.1 Start 64,170,057 bp[2] End 64,446,491 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon secondary oocyte buccal mucosa cell sural nerve sperm tendon of biceps brachii corpus callosum epithelium of colon internal globus pallidus testicle Top expressed in spermatid otic placode spermatocyte saccule primary oocyte secondary oocyte esophagus tail of embryo zygote genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity epidermal growth factor receptor binding non-membrane spanning protein tyrosine kinase activity kinase activity protein phosphatase 1 binding protein binding protein tyrosine kinase activity ATP binding lipid binding Cellular component cytoplasm cell projection membrane microtubule cytoskeleton extrinsic component of cytoplasmic side of plasma membrane plasma membrane cell junction cell cortex actin cytoskeleton cytoskeleton nucleus lamellipodium cytosol Biological process regulation of protein phosphorylation regulation of lamellipodium assembly actin cytoskeleton reorganization diapedesis cell differentiation intracellular signal transduction positive regulation of actin filament polymerization extracellular matrix-cell signaling phosphorylation cytokine-mediated signaling pathway Kit signaling pathway positive regulation of cell migration regulation of epidermal growth factor receptor signaling pathway response to platelet-derived growth factor cellular response to macrophage colony-stimulating factor stimulus cell-cell adhesion mediated by cadherin cellular response to reactive oxygen species chemotaxis protein phosphorylation Fc-epsilon receptor signaling pathway interleukin-6-mediated signaling pathway response to lipopolysaccharide cell adhesion positive regulation of NF-kappaB transcription factor activity positive regulation of cell population proliferation insulin receptor signaling pathway via phosphatidylinositol 3-kinase cellular response to insulin stimulus mitotic cell cycle peptidyl-tyrosine autophosphorylation negative regulation of mast cell activation involved in immune response protein autophosphorylation peptidyl-tyrosine phosphorylation substrate adhesion-dependent cell spreading regulation of mast cell degranulation platelet-derived growth factor receptor signaling pathway cell population proliferation regulation of fibroblast migration innate immune response microtubule cytoskeleton organization signal transduction tyrosine phosphorylation of STAT protein regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2241 14158 Ensembl ENSG00000151422 ENSMUSG00000000127 UniProt P16591 P70451 RefSeq (mRNA) NM_001308028 NM_001308031 NM_001308038 NM_005246 NM_001037997 NM_001286415 NM_008000 RefSeq (protein) NP_001294957 NP_001294960 NP_001294967 NP_005237 NP_001033086 NP_001273344 NP_032026 Location (UCSC) Chr 5: 108.75 – 109.2 Mb Chr 17: 64.17 – 64.45 Mb PubMed search [3] [4]
Wikidata
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Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.^[5]

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.^[5]

Interactions[edit]

FER (gene) has been shown to interact with TMF1^[6] and Cortactin.^[7]

References[edit]

Further reading[edit]

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