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FMR1-AS1 gene

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FMR1-AS1

Identifiers

Aliases

FMR1-AS1, ASFMR1, FMR1-AS, FMR1AS, FMR4, FMR1-AS1 gene, FMR1 antisense RNA 1, FMR1 antisense RNA 1 (head to head)

External IDs

OMIM: 300805; GeneCards: FMR1-AS1; OMA:FMR1-AS1 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xq27.3	Start	147,909,431 bp^[1]
Band	Xq27.3	End	147,911,817 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

ganglionic eminence

lymph node

liver

skeletal muscle tissue

duodenum

prefrontal cortex

gallbladder

blood

olfactory zone of nasal mucosa

n/a

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


100126270


n/a

Ensembl


ENSG00000268066


n/a

UniProt


n a


n/a

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr X: 147.91 – 147.91 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

In molecular biology, FMR1 antisense RNA 1 (FMR1-AS1), also known as ASFMR1 or FMR4, is a long non-coding RNA. The FMR1-AS1 gene overlaps, and is antisense to, the CGG repeat region of the FMR1 gene.^[3] Its expression is upregulated in fragile X syndrome premutation carriers, and silenced in patients with fragile X syndrome.^[3]^[4] FMR1-AS1 has an anti-apoptotic function.^[4]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000268066 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ ^a ^b Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS, et al. (2007). "An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals". Hum Mol Genet. 16 (24): 3174–3187. doi:10.1093/hmg/ddm293. PMID 17921506.

^ ^a ^b Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C (2008). "A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome". PLOS ONE. 3 (1): e1486. Bibcode:2008PLoSO...3.1486K. doi:10.1371/journal.pone.0001486. PMC 2194623. PMID 18213394.

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