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Contents

   



(Top)
  


1 References  




2 Further reading  













FRMD6






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From Wikipedia, the free encyclopedia
  

FRMD6

Identifiers

Aliases

FRMD6, C14orf31, EX1, Willin, c14_5320, FERM domain containing 6

External IDs

OMIM: 614555; MGI: 2442579; HomoloGene: 12449; GeneCards: FRMD6; OMA:FRMD6 - orthologs

Gene location (Human)

Chromosome 14 (human)

Chr.

Chromosome 14 (human)[1]

Chromosome 14 (human)

Genomic location for FRMD6

Genomic location for FRMD6

Band

14q22.1

Start

51,489,100 bp[1]

End

51,730,727 bp[1]

Gene location (Mouse)

Chromosome 12 (mouse)

Chr.

Chromosome 12 (mouse)[2]

Chromosome 12 (mouse)

Genomic location for FRMD6

Genomic location for FRMD6

Band

12|12 C2

Start

70,872,288 bp[2]

End

70,949,008 bp[2]

Bgee

Mouse (ortholog)

  • skin of arm

  • cartilage tissue

  • tibia

  • tail of epididymis

  • stromal cell of endometrium

  • epithelium of lactiferous gland

  • lactiferous duct

  • oral cavity

  • skin of thigh

  • skin of hip
    • calvaria

  • skin of external ear

  • hair follicle

  • ankle joint

  • body of femur

  • skin of back

  • corneal stroma

  • lip

  • conjunctival fornix

  • sciatic nerve

    • More reference expression data

    BioGPS

    n/a

    Molecular function

  • structural constituent of cytoskeleton

    • Cellular component

  • plasma membrane
  • membrane
  • cytoplasm
  • cytoskeleton

    • Biological process

  • apical constriction
  • actomyosin structure organization

    • Sources:Amigo / QuickGO

    Species

    Human

    Mouse

    Entrez

    122786

    319710

    Ensembl

    ENSG00000139926

    ENSMUSG00000048285

    UniProt

    Q96NE9

    Q8C0V9

    RefSeq (mRNA)

    NM_001042481
    NM_001267046
    NM_001267047
    NM_152330

    NM_028127

    RefSeq (protein)

    NP_001035946
    NP_001253975
    NP_001253976
    NP_689543

    NP_082403

    Location (UCSC)

    Chr 14: 51.49 – 51.73 Mb

    Chr 12: 70.87 – 70.95 Mb

    PubMed search

    [3]

    [4]

    Wikidata

    FERM domain-containing protein 6 is a protein that in humans is encoded by the FRMD6 gene.[5]

    References[edit]

    1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139926 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048285 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Entrez Gene: FRMD6 FERM domain containing 6".

    • Further reading[edit]

  • Moleirinho S, Patrick C, Tilston-Lünel AM, Higginson JR, Angus L, Antkowiak M, Barnett SC, Prystowsky MB, Reynolds PA, Gunn-Moore FJ (2013). "Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts". PLOS ONE. 8 (4): e60028. Bibcode:2013PLoSO...860028M. doi:10.1371/journal.pone.0060028. PMC 3620498. PMID 23593160.
  • Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ (January 2012). "Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP". Oncogene. 31 (2): 238–50. doi:10.1038/onc.2011.224. hdl:10023/2489. PMID 21666719.
  • Madan R, Brandwein-Gensler M, Schlecht NF, Elias K, Gorbovitsky E, Belbin TJ, Mahmood R, Breining D, Qian H, Childs G, Locker J, Smith R, Haigentz M, Gunn-Moore F, Prystowsky MB (November 2006). "Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic significance for head and neck squamous cell carcinoma". Head & Neck. 28 (11): 1018–27. doi:10.1002/hed.20435. PMID 16783828. S2CID 32305188.
  • Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G (January 2006). "The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis". Nature Cell Biology. 8 (1): 27–36. doi:10.1038/ncb1339. PMID 16341207. S2CID 15468669.
  • Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S, Brandwein-Gensler M, Madan R, Tavaré JM, Brophy PJ, Prystowsky MB, Guild S (September 2005). "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'" (PDF). FEBS Letters. 579 (22): 5089–94. doi:10.1016/j.febslet.2005.07.097. PMID 16137681.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.


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    ●This page was last edited on 30 March 2024, at 10:55 (UTC).
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