Jump to content

Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

(Top) 1 References 2 Further reading

FRMD6

●العربية ●مصرى ●Татарча / tatarça ●Українська Edit links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version Appearance From Wikipedia, the free encyclopedia

FRMD6

Identifiers

Aliases

FRMD6, C14orf31, EX1, Willin, c14_5320, FERM domain containing 6

External IDs

OMIM: 614555; MGI: 2442579; HomoloGene: 12449; GeneCards: FRMD6; OMA:FRMD6 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q22.1	Start	51,489,100 bp^[1]
Band	14q22.1	End	51,730,727 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 C2	Start	70,872,288 bp^[2]
Band	12\|12 C2	End	70,949,008 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of arm

cartilage tissue

tibia

tail of epididymis

stromal cell of endometrium

epithelium of lactiferous gland

lactiferous duct

oral cavity

skin of thigh

skin of hip

Top expressed in

calvaria

skin of external ear

hair follicle

ankle joint

body of femur

skin of back

corneal stroma

lip

conjunctival fornix

sciatic nerve

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding structural constituent of cytoskeleton
Cellular component	apical junction complex plasma membrane membrane cytoplasm cytoskeleton
Biological process	regulation of actin filament-based process apical constriction actomyosin structure organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


122786


319710

Ensembl


ENSG00000139926


ENSMUSG00000048285

UniProt


Q96NE9


Q8C0V9

RefSeq (mRNA)


NM_001042481 NM_001267046 NM_001267047 NM_152330


NM_028127

RefSeq (protein)


NP_001035946 NP_001253975 NP_001253976 NP_689543


NP_082403

Location (UCSC)

Chr 14: 51.49 – 51.73 Mb

Chr 12: 70.87 – 70.95 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

FERM domain-containing protein 6 is a protein that in humans is encoded by the FRMD6 gene.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139926 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048285 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: FRMD6 FERM domain containing 6".

Further reading[edit]

Kronenberg NM, Tilston-Lunel A, Thompson FE, Chen D, Yu W, Dholakia K, Gather MC, Gunn-Moore FJ (2020). "Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity". Frontiers in Cellular Neuroscience. 14: 552213. doi:10.3389/fncel.2020.552213. PMC 7498650. PMID 33088261.

Moleirinho S, Patrick C, Tilston-Lünel AM, Higginson JR, Angus L, Antkowiak M, Barnett SC, Prystowsky MB, Reynolds PA, Gunn-Moore FJ (2013). "Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts". PLOS ONE. 8 (4): e60028. Bibcode:2013PLoSO...860028M. doi:10.1371/journal.pone.0060028. PMC 3620498. PMID 23593160.

Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ (January 2012). "Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP". Oncogene. 31 (2): 238–50. doi:10.1038/onc.2011.224. hdl:10023/2489. PMID 21666719.

Madan R, Brandwein-Gensler M, Schlecht NF, Elias K, Gorbovitsky E, Belbin TJ, Mahmood R, Breining D, Qian H, Childs G, Locker J, Smith R, Haigentz M, Gunn-Moore F, Prystowsky MB (November 2006). "Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic significance for head and neck squamous cell carcinoma". Head & Neck. 28 (11): 1018–27. doi:10.1002/hed.20435. PMID 16783828. S2CID 32305188.

Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G (January 2006). "The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis". Nature Cell Biology. 8 (1): 27–36. doi:10.1038/ncb1339. PMID 16341207. S2CID 15468669.

Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S, Brandwein-Gensler M, Madan R, Tavaré JM, Brophy PJ, Prystowsky MB, Guild S (September 2005). "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'" (PDF). FEBS Letters. 579 (22): 5089–94. doi:10.1016/j.febslet.2005.07.097. PMID 16137681.

Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=FRMD6&oldid=1216324640" Categories: ●Genes on human chromosome 14 ●Human chromosome 14 gene stubs Hidden categories: ●Articles with short description ●Short description matches Wikidata ●All stub articles ●This page was last edited on 30 March 2024, at 10:55 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view