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File:Replication-transcription complex for Coronaviruses.tif




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File:Replication-transcription complex for Coronaviruses.tif
Size of this JPG preview of this TIF file: 668 × 600 pixels. Other resolutions: 267 × 240 pixels | 535 × 480 pixels | 855 × 768 pixels | 1,141 × 1,024 pixels | 1,448 × 1,300 pixels.

Original file(1,448 × 1,300 pixels, file size: 374 KB, MIME type: image/tiff)





Summary

Description
English: CoV genomic architecture and nonstructural proteins (nsps): A. Shown is a linear schematic of the SARS-CoV genome containing both the nonstructural protein (nsp) and the structural and accessory protein open reading frames. The −1 ribosomal frameshift between nsps 10 and 12 is shown by the offset boxes. Boxes denoting each individual nsp are scaled according to amino acid length, and products of polyprotein 1a (nsps1–10) and 1ab (nsps12–16) processing are shown. Colors are as follows: orange (nsp7), green (nsp8), cyan (nsp9), yellow (nsp10), red (nsp12: RNA-dependent RNA polymerase [RdRp]), and blue (nsp14: 3′-to-5′ exoribonuclease [ExoN] and N7-methyltranferase [N7-MTase]). B. A linear schematic of nsp14 is shown. The ExoN domain is colored solid blue, while the N7-MTase domain is hatched blue and white. The zinc-finger domain (ZnF) is shown in gray. DE-D-D residues characteristic of the DEDDh exonuclease superfamily [10] are shown as white boxes. C. A model of how nsps7–8 could assemble on viral dsRNA and interact with the putative multi-subunit CoV polymerase complex consisting of nsps10, 12, and 14. Colors are the same as in panel A, except the two forms of nsp8 (I and II) are shown in green and light green respectively. A short (∼6 n.t.) primer generated by the non-canonical RdRp activity of nsp8 is shown. Binding of ssRNA by nsp9 is also shown.
Date
Source https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003760
Author Everett Clinton Smith, Mark R. Denison
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This file is licensed under the Creative Commons Attribution 3.0 Unported license.
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    Replication-transcription complex for Coronaviruses

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    5 December 2013

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    Date/TimeThumbnailDimensionsUserComment
    current08:20, 9 March 2020Thumbnail for version as of 08:20, 9 March 20201,448 × 1,300 (374 KB)Guest2625Uploaded a work by Everett Clinton Smith, Mark R. Denison from https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003760 with UploadWizard



    The following pages on the English Wikipedia use this file (pages on other projects are not listed):

    ORF1ab

    SARS-related coronavirus


    Global file usage


    The following other wikis use this file:

    Usage on ar.wikipedia.org

    فيروس كورونا

    فيروس كورونا المرتبط بالمتلازمة التنفسية الحادة الشديدة

    ORF1ab


    Usage on cs.wikipedia.org

    SARS-CoV-2


    Usage on fr.wikipedia.org

    Coronavirus lié au syndrome respiratoire aigu sévère

    Utilisateur:Polaert/cov2

    Utilisateur:Polaert/CycleCoV2

    Cycle de réplication du SARS-CoV-2

    Utilisateur:Polaert/CRT


    Usage on gl.wikipedia.org

    SARSr-CoV


    Usage on vi.wikipedia.org

    Virus corona liên quan đến hi chng hô hp cp tính nng



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    Retrieved from "https://en.wikipedia.org/wiki/File:Replication-transcription_complex_for_Coronaviruses.tif"







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