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1 References  














Fusion transcript






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From Wikipedia, the free encyclopedia
 


Fusion transcript is a chimeric RNA encoded by a fusion gene[1] or by two different genes by subsequent trans-splicing.[2][3] Certain fusion transcripts are commonly produced by cancer cells, and detection of fusion transcripts is part of routine diagnostics of certain cancer types.

References

[edit]
  1. ^ Mitelman; Johansson, B; Mertens, F (2007). "The impact of translocations and gene fusions on cancer causation". Nature Reviews. Cancer. 7 (4): 233–45. doi:10.1038/nrc2091. PMID 17361217. S2CID 26093482.
  • ^ Li; Wang, J; Mor, G; Sklar, J (2008). "A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells". Science. 321 (5894): 1357–61. Bibcode:2008Sci...321.1357L. doi:10.1126/science.1156725. PMID 18772439. S2CID 13605087.
  • ^ Rickman, F; Pflueger, D; Moss, B; Vandoren, VE; Chen, CX; De La Taille, A; Kuefer, R; Tewari, AK; et al. (2009). "SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer". Cancer Research. 69 (7): 2734–8. doi:10.1158/0008-5472.CAN-08-4926. PMC 4063441. PMID 19293179.

  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Fusion_transcript&oldid=1059489935"

    Categories: 
    Mutation
    Spliceosome
    RNA splicing
     



    This page was last edited on 9 December 2021, at 19:33 (UTC).

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