Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.[4][5][6] It is found within the nucleolus that binds p53.[7] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.[7] It is a marker for many stem cells and cancer cells.[8]
GNL3 has been shown to interact with Mdm2[9] and P53.[5]
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