Contents

GPR116

Protein-coding gene in the species Homo sapiens

ADGRF5
Identifiers
Aliases	ADGRF5, KPG_001, GPR116, adhesion G protein-coupled receptor F5
External IDs	MGI: 2182928; HomoloGene: 9065; GeneCards: ADGRF5; OMA:ADGRF5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.3 Start 46,852,522 bp[1] End 46,954,943 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B3 Start 43,671,342 bp[2] End 43,770,448 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung visceral pleura right lung upper lobe of lung upper lobe of left lung renal medulla right ventricle metanephric glomerulus vena cava pericardium Top expressed in right lung right lung lobe left lung lobe endothelial cell of lymphatic vessel interventricular septum myocardium of ventricle extraocular muscle digastric muscle soleus muscle brown adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane cell surface plasma membrane apical part of cell cytoplasmic vesicle membrane Biological process surfactant homeostasis negative regulation of macrophage activation G protein-coupled receptor signaling pathway cell surface receptor signaling pathway energy reserve metabolic process regulation of lipid metabolic process fat cell differentiation positive regulation of phospholipid biosynthetic process glucose homeostasis signal transduction glomerular filtration erythrocyte development pharyngeal arch artery morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221395 224792 Ensembl ENSG00000069122 ENSMUSG00000056492 UniProt Q8IZF2 G5E8Q8 RefSeq (mRNA) NM_001098518 NM_015234 NM_001081178 NM_001357332 RefSeq (protein) NP_001091988 NP_056049 NP_001074647 NP_001344261 NP_001391458 NP_001391459 NP_001391465 NP_001391470 NP_001391475 NP_001391477 Location (UCSC) Chr 6: 46.85 – 46.95 Mb Chr 17: 43.67 – 43.77 Mb PubMed search [3] [4]
Wikidata
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Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene.^[5][6][7] GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.^[8][9]

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