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(Top) 1 Function 2 References 3 Further reading

GPR34

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GPR34

Identifiers

Aliases

GPR34, LYPSR1, G protein-coupled receptor 34

External IDs

OMIM: 300241; MGI: 1346334; HomoloGene: 36174; GeneCards: GPR34; OMA:GPR34 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xp11.4	Start	41,688,973 bp^[1]
Band	Xp11.4	End	41,697,275 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X\|X A1.1	Start	13,498,328 bp^[2]
Band	X\|X A1.1	End	13,507,097 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

smooth muscle tissue

testicle

placenta

mucosa of ileum

right coronary artery

appendix

gallbladder

rectum

monocyte

Top expressed in

lumbar subsegment of spinal cord

stroma of bone marrow

dentate gyrus of hippocampal formation granule cell

mesenteric lymph nodes

Region I of hippocampus proper

superior frontal gyrus

primary visual cortex

spleen

ankle

embryo

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	G protein-coupled purinergic nucleotide receptor activity G protein-coupled receptor activity signal transducer activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	G protein-coupled receptor signaling pathway signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2857


23890

Ensembl


ENSG00000171659


ENSMUSG00000040229

UniProt


Q9UPC5


Q9R1K6

RefSeq (mRNA)


NM_001033513 NM_001033514 NM_001097579 NM_005300


NM_011823

RefSeq (protein)


NP_001091048 NP_005291


NP_035953

Location (UCSC)

Chr X: 41.69 – 41.7 Mb

Chr X: 13.5 – 13.51 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.^[5]^[6]^[7]

Function[edit]

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171659 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040229 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Schöneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (July 1999). "A novel subgroup of class I G-protein-coupled receptors". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (1–2): 57–70. doi:10.1016/s0167-4781(99)00081-0. PMID 10395919.

^ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (February 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.

^ ^a ^b "Entrez Gene: GPR34 G protein-coupled receptor 34".

Further reading[edit]

Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.

Jacobi FK, Broghammer M, Pesch K, Zrenner E, Berger W, Meindl A, Pusch CM (July 2000). "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1". Human Genetics. 107 (1): 89–91. doi:10.1007/s004390050017. PMID 10982042.

Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

Engemaier E, Römpler H, Schöneberg T, Schulz A (February 2006). "Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34". Genomics. 87 (2): 254–64. doi:10.1016/j.ygeno.2005.10.001. PMID 16338117.

Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.

Liebscher I, Müller U, Teupser D, Engemaier E, Engel KM, Ritscher L, Thor D, Sangkuhl K, Ricken A, Wurm A, Piehler D, Schmutzler S, Fuhrmann H, Albert FW, Reichenbach A, Thiery J, Schöneberg T, Schulz A (January 2011). "Altered immune response in mice deficient for the G protein-coupled receptor GPR34". The Journal of Biological Chemistry. 286 (3): 2101–10. doi:10.1074/jbc.M110.196659. PMC 3023507. PMID 21097509.

Ritscher L, Engemaier E, Stäubert C, Liebscher I, Schmidt P, Hermsdorf T, Römpler H, Schulz A, Schöneberg T (May 2012). "The ligand specificity of the G-protein-coupled receptor GPR34". The Biochemical Journal. 443 (3): 841–50. doi:10.1042/BJ20112090. PMID 22348703.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)