Glutamate receptor delta-1 subunit also known as GluD1orGluRδ1 is a transmembrane protein[5][6] (1009 aa) encoded by the GRID1 gene.[7][8] A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.[9]
This gene encodes a subunit of glutamate receptor ligand-gated ion channel. Most of these channels mediate fast excitatory synaptic transmission in the central nervous system. GluD1 is expressed in the central nervous system[10] and is important in synaptic plasticity.[7][11]
Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.[12][13]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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| Cys-loop receptors |
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| Ionotropic glutamates |
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| ATP-gated channels |
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 | This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it. |
