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1 References  













GSK 299423






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From Wikipedia, the free encyclopedia
  

GSK 299423
Names
Preferred IUPAC name

6-Methoxy-4-[2-(4-{[(2H-[1,3]oxathiolo[5,4-c]pyridin-6-yl)methyl]amino}piperidin-1-yl)ethyl]quinoline-3-carbonitrile

Identifiers

CAS Number

3D model (JSmol)
ChemSpider

PubChem CID
UNII

CompTox Dashboard (EPA)

  • InChI=1S/C25H27N5O2S/c1-31-20-2-3-23-22(11-20)21(17(12-26)13-29-23)6-9-30-7-4-18(5-8-30)27-14-19-10-25-24(15-28-19)32-16-33-25/h2-3,10-11,13,15,18,27H,4-9,14,16H2,1H3 checkY

    Key: NKXJSCXEAVZSMF-UHFFFAOYSA-N checkY

  • COc1ccc2c(c1)c(c(cn2)C#N)CCN3CCC(CC3)NCc4cc5c(cn4)OCS5

Properties

Chemical formula

 C25H27N5O2S
Molar mass 461.58 g·mol−1

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

☒N verify (what is checkY☒N ?)

Infobox references

3D protein map of GSK 299423 (yellow) in complex with Staphylococcus aureus DNA gyrase (teal) and a DNA fragment (orange). From PDB: 2xcs​.

GSK 299423orGlaxoSmithKline 299423 is an antibiotic chemical compound that has been identified as potentially effective in treating patients infected with bacteria expressing the New Delhi metallo-beta-lactamase. The antibiotic inhibits the enzyme topoisomerase, which bacteria need to replicate.[1][2][3]

No animal studies have been reported. No application has been made for human clinical trials.[citation needed]

References[edit]

  1. ^ Sten Stovall, "Glaxo:New Compound Offers Way To Fight Drug-Resistant Bacteria[permanent dead link]," The Wall Street Journal, August 4, 2010
  • ^ Melly Alazraki, "GlaxoSmithKline Finds Compound That Could Help Fight 'Superbugs' Archived 2010-08-16 at the Wayback Machine" Daily Finance, August 6, 2010
  • ^ Bax BD, et al. (4 August 2010). "Type IIA topoisomerase inhibition by a new class of antibacterial agents". Nature. 466 (7309): 935–40. Bibcode:2010Natur.466..935B. doi:10.1038/nature09197. PMID 20686482. S2CID 205221405. (primary source)


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=GSK_299423&oldid=1132015680"
    Categories: 
    ●Antibiotics
     ●Quinolines
     ●Piperidines
     ●Nitriles
     ●Phenol ethers
     ●Oxygen heterocycles
     ●Sulfur heterocycles
     ●Nitrogen heterocycles
     ●Heterocyclic compounds with 2 rings
     ●Antibiotic stubs
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    ●This page was last edited on 6 January 2023, at 21:42 (UTC).
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