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F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Brazilian biochemist (1923-1994)
Giuseppe Cilento (July 21, 1923 in Sorrento , Italy – October 31, 1994 in São Paulo ) was a Brazilian chemist who was born in Italy . He held a professorship at the University of São Paulo and was Professor Emeritus at the State University of Campinas .
Early life and education [ edit ]
Cilento attended the Department of Chemistry, Faculty of Philosophy, Science and Letters, University of São Paulo, São Paulo, Brazil.
Cilento completed a post-doc at Harvard University .[1]
Awards and honors [ edit ]
He received the grã-cruz ("Great Cross") of the Ordem Nacional do Mérito Científico [2] TWAS Prize in 1993.[3]
Cilento may have been awarded fellowship by the John Simon Guggenheim Memorial Foundation in 1977 and 1981.[4]
The Rockefeller Foundation awarded $4,905 to Cilento and Heinrich Hauptmann for biochemistry research in 1958.
Contributions [ edit ]
Throughout his career, Cilento published over 150 papers.[5]
Cilento was an early pioneer of the paradoxical hypothesis of "photochemistry without light".[6] chemiluminescence and bioluminescence originating from enzymatic and non-enzymatic pathways that produce unstable peroxide intermediates such as 1,2-dioxetanes that fluoresce , ejecting a photon within "dark" biological organisms potentially triggering physiological or pathophysiological responses.[6] horseradish peroxidase .
An example mechanism resides in keto acids such as phenylpyruvic acid , which under certain circumstances tautomerizes to form a reactive enol . Peroxidation, initiated by reactive oxygen species by enzymatic peroxidases or non-enzymatic pathways, react with the benzylic carbon and alpha-keto carbonyl to form a "squaric" 1,2-dioxetane /dioxetanol. This intermediate is unstable, resulting in the ejection of a photon and subsequent formation of oxalic acid and benzaldehyde in the triplet state .[7] peroxylactone that forms benzaldehyde and carbon dioxide and carbon monoxide . Cilento and Villablanca were interested in the biological significance of this specific pathway among others.[8]
Among Cilento's collaborators, many publications on dark-photochemistry were authored with Prof. Waldemar Adam at University of Würzburg . Cilento and Adam described how 1,2-dioxetanes can induce chemical modification of DNA including formation of cyclobutane pyrimidine dimers and oxidation of guanine (from a triplet-state carbonyl and subsequent reactivity with oxygen, exemplified by the phenylpyruvate 1,2-dioxetanol pathway).[6]
External links [ edit ]
^ "Prizes and Awards" . The World Academy of Sciences. 2016.
^ "John Simon Guggenheim Foundation | Giuseppe Cilento" . Retrieved 2021-06-01 .
^ "001. Science and Literature: Global and Local Perspectives" (PDF) .
^ a b c Baader, Wilhelm J.; Stevani, Cassius V.; Bechara, Etelvino J. H. (2015). " . Journal of the Brazilian Chemical Society . doi :10.5935/0103-5053.20150257 ISSN 0103-5053 .
^ Hopper, Christopher P.; De La Cruz, Ladie Kimberly; Lyles, Kristin V.; Wareham, Lauren K.; Gilbert, Jack A.; Eichenbaum, Zehava; Magierowski, Marcin; Poole, Robert K.; Wollborn, Jakob; Wang, Binghe (2020-12-23). "Role of Carbon Monoxide in Host–Gut Microbiome Communication" . Chemical Reviews . 120 (24 ): 13273–13311. doi :10.1021/acs.chemrev.0c00586 . ISSN 0009-2665 . PMID 33089988 . S2CID 224824871 .
^ Hopper, Christopher P.; Zambrana, Paige N.; Goebel, Ulrich; Wollborn, Jakob (2021). "A brief history of carbon monoxide and its therapeutic origins" . Nitric Oxide . 111–112: 45–63. doi :10.1016/j.niox.2021.04.001 . PMID 33838343 . S2CID 233205099 .
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Giuseppe_Cilento&oldid=1177443861 " C a t e g o r i e s : ● 1 9 2 3 b i r t h s ● 1 9 9 4 d e a t h s ● B r a z i l i a n s c i e n t i s t s ● R e c i p i e n t s o f t h e G r e a t C r o s s o f t h e N a t i o n a l O r d e r o f S c i e n t i f i c M e r i t ( B r a z i l ) ● P e o p l e f r o m S o r r e n t o ● A c a d e m i c s t a f f o f t h e U n i v e r s i t y o f S ã o P a u l o ● A c a d e m i c s t a f f o f t h e S t a t e U n i v e r s i t y o f C a m p i n a s ● I t a l i a n e m i g r a n t s t o B r a z i l ● T W A S l a u r e a t e s ● B r a z i l i a n s c i e n t i s t s t u b s H i d d e n c a t e g o r i e s : ● A l l a r t i c l e s w i t h d e a d e x t e r n a l l i n k s ● A r t i c l e s w i t h d e a d e x t e r n a l l i n k s f r o m J a n u a r y 2 0 1 8 ● A r t i c l e s w i t h p e r m a n e n t l y d e a d e x t e r n a l l i n k s ● C S 1 : l o n g v o l u m e v a l u e ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n i s d i f f e r e n t f r o m W i k i d a t a ● A r t i c l e s w i t h h C a r d s ● A r t i c l e s w i t h I S N I i d e n t i f i e r s ● A r t i c l e s w i t h V I A F i d e n t i f i e r s ● A r t i c l e s w i t h B I B S Y S i d e n t i f i e r s ● A r t i c l e s w i t h J 9 U i d e n t i f i e r s ● A r t i c l e s w i t h L C C N i d e n t i f i e r s ● A r t i c l e s w i t h N T A i d e n t i f i e r s ● A r t i c l e s w i t h S U D O C i d e n t i f i e r s ● A l l s t u b a r t i c l e s
● T h i s p a g e w a s l a s t e d i t e d o n 2 7 S e p t e m b e r 2 0 2 3 , a t 1 6 : 2 1 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
