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Contents

   



(Top)
  


1 See also  




2 References  




3 External links  













Glesatinib







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From Wikipedia, the free encyclopedia
  

Glesatinib
Clinical data
Routes of
administration		By mouth
ATC code
  • None
Legal status
Legal status
  • Investigational
Identifiers

  • N-[(3-Fluoro-4-{[2-(5-{[(2-methoxyethyl)amino]methyl}-2-pyridinyl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)carbamothioyl]-2-(4-fluorophenyl)acetamide

CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC31H27F2N5O3S2
Molar mass619.71 g·mol−1
3D model (JSmol)

  • COCCNCc1ccc(nc1)c2cc3c(s2)c(ccn3)Oc4ccc(cc4F)NC(=S)NC(=O)Cc5ccc(cc5)F

  • InChI=1S/C31H27F2N5O3S2/c1-40-13-12-34-17-20-4-8-24(36-18-20)28-16-25-30(43-28)27(10-11-35-25)41-26-9-7-22(15-23(26)33)37-31(42)38-29(39)14-19-2-5-21(32)6-3-19/h2-11,15-16,18,34H,12-14,17H2,1H3,(H2,37,38,39,42)

  • Key:YRCHYHRCBXNYNU-UHFFFAOYSA-N

Glesatinib (MGCD265) is an experimental anti-cancer drug.[1][2]

It is in phase 2 clinical trials for non-small cell lung cancer (NSCLC).[3]

It is a spectrum selective tyrosine[1] kinase inhibitor "for the treatment of non-small cell lung cancer (NSCLC) patients with genetic alterations of MET".[4]

See also[edit]

References[edit]

  1. ^ a b "Glesatinib". NCI Dictionaries. National Cancer Institute at the National Institutes of Health. U.S. Department of Health and Human Services. Archived from the original on 2017-01-16. Retrieved 2017-01-15.
  • ^ Cui Q, Cai CY, Gao HL, Ren L, Ji N, Gupta P, Yang Y, Shukla S, Ambudkar SV, Yang DH, Chen ZS (2019). "Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells". Frontiers in Oncology. 9: 313. doi:10.3389/fonc.2019.00313. PMC 6494935. PMID 31106148.
  • ^ Clinical trial number NCT02954991 for "Phase 2 Study of Glesatinib, Sitravatinib or Mocetinostat in Combination With Nivolumab in Non-Small Cell Lung Cancer " at ClinicalTrials.gov
  • ^ "Mirati Therapeutics Provides Update On Glesatinib And Sitravatinib Clinical Trials And Pipeline Programs". PipelineReview.com. January 2017.

    • External links[edit]


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Glesatinib&oldid=1227740528"
    Categories: 
    ●Drugs not assigned an ATC code
     ●Tyrosine kinase inhibitors
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     ●Fluoroarenes
     ●Experimental cancer drugs
     ●Antineoplastic and immunomodulating drug stubs
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     ●Drugs with non-standard legal status
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