The railroad was established by John G. Heimrich, a late 19th Century entrepreneur of German ancestry. Construction of the railroad was started on April 8, 1904, and was completed on July 1, 1913 with the establishment of regular train service from The Dalles to Friend. The Great Southern served agricultural and timber interests on the Columbia Plateau south of The Dalles and eastern slopes of Mount Hood. The general offices for the Great Southern were located in The Dalles, Oregon. The General Officers of the company, listed in 1925, were as follows:
The Great Southern's revenues reached a peak in 1910, but leveled off into the early 1920s. With the introduction of regular bus service, and an increase in automobile and truck traffic between The Dalles and Dufur, revenues began to decline after 1921. Regular train service came to an end on January 5, 1928 with the closing of the depots at Dufur and Friend. Attempts to resurrect the line as The Dalles and Southern failed in 1933. The line was officially abandoned on September 30, 1935. Very little of the Great Southern remains to this day. The Dalles depot, which was moved from its original location to its current site at the base of Brewery Grade, is the most visible relic of this short-lived Oregon railroad.
Due, John F. and French, Giles. Rails to the Mid-Columbia Wheatlands: The Columbia Southern and Great Southern Railroads and the Development of Sherman and Wasco Counties, Oregon. Washington D.C.: University Press of America, Inc., 1979.
Brown, Harold A., and Wilson, B.J. The Official Railway Equipment Register. New York: The Railway Equipment and Publication Company, January 1925.