Jump to content

Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

(Top) 1 References

Guadinomine

Add links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version Appearance From Wikipedia, the free encyclopedia

Chemical structure of guadinomine B

Guadinomines are anti-infective compounds produced by Streptomyces sp. K01-0509.^[1] Guadinomine B is the most potent known inhibitor of the Type III secretion system (TTSS) of Gram-negative bacteria. The guadinomine (gdn) biosynthetic gene cluster includes 26 open reading frames spanning 51.2 kb. Streptomyces sp. K01-0509 produces several derivatives named guadinomines A, B, C1, C2, D, and guadinomic acid.^[2]

References[edit]

^ Iwatsuki, Masato; Uchida, Ryuji; Yoshijima, Hitomi; Ui, Hideaki; Shiomi, Kazuro; Matsumoto, Atsuko; Takahashi, Yoko; Abe, Akio; Tomoda, Hiroshi; Ōmura, Satoshi (2008). "Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509". The Journal of Antibiotics. 61 (4): 222–229. doi:10.1038/ja.2008.32. PMID 18503201.

^ Holmes, T. C.; May, A. E.; Zaleta-Rivera, K.; Ruby, J. G.; Skewes-Cox, P.; Fischbach, M. A.; Derisi, J. L.; Iwatsuki, M.; Ōmura, S.; Khosla, C. (2012). "Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor". Journal of the American Chemical Society. 134 (42): 17797–17806. doi:10.1021/ja308622d. PMC 3483642. PMID 23030602.

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Guadinomine&oldid=1095446166" Categories: ●Anti-infective agents ●Antiinfective agent stubs Hidden category: ●All stub articles ●This page was last edited on 28 June 2022, at 11:55 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view