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Contents

   



(Top)
  


1 Interactions  




2 References  




3 Further reading  













HBXIP






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From Wikipedia, the free encyclopedia
  

LAMTOR5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLAMTOR5, HBXIP, XIP, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
External IDsOMIM: 608521; MGI: 1915826; HomoloGene: 4668; GeneCards: LAMTOR5; OMA:LAMTOR5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10542

68576

Ensembl

ENSG00000134248

ENSMUSG00000087260

UniProt

O43504

Q9D1L9

RefSeq (mRNA)

NM_006402
NM_001382293

NM_026774

RefSeq (protein)

NP_006393
NP_001369222
NP_006393.2

NP_081050

Location (UCSC)Chr 1: 110.4 – 110.41 MbChr 3: 107.19 – 107.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.[5][6]

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.[6]

Interactions

[edit]

HBXIP has been shown to interact with NCOA6.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134248 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000087260 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ Melegari M, Scaglioni PP, Wands JR (March 1998). "Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication". Journal of Virology. 72 (3): 1737–43. doi:10.1128/jvi.72.3.1737-1743.1998. PMC 109461. PMID 9499022.
  • ^ a b "Entrez Gene: HBXIP hepatitis B virus x interacting protein".
  • ^ Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.

    • Further reading

    [edit]
  • Li Y, Lu YY (April 2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World Journal of Gastroenterology. 8 (2): 213–6. doi:10.3748/wjg.v8.i2.213. PMC 4658353. PMID 11925594.
  • Marusawa H, Matsuzawa S, Welsh K, Zou H, Armstrong R, Tamm I, Reed JC (June 2003). "HBXIP functions as a cofactor of survivin in apoptosis suppression". The EMBO Journal. 22 (11): 2729–40. doi:10.1093/emboj/cdg263. PMC 156760. PMID 12773388.
  • Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.
  • Lee SH, Park SG, Lim SO, Jung G (June 2005). "The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1741 (1–2): 75–84. doi:10.1016/j.bbadis.2004.10.004. PMID 15955450.
  • Lee AT, Ren J, Wong ET, Ban KH, Lee LA, Lee CG (September 2005). "The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage". The Journal of Biological Chemistry. 280 (39): 33525–35. doi:10.1074/jbc.M506628200. PMID 16055925.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Minczuk M, Mroczek S, Pawlak SD, Stepien PP (October 2005). "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP". The FEBS Journal. 272 (19): 5008–19. doi:10.1111/j.1742-4658.2005.04910.x. PMID 16176273. S2CID 40846992.
  • Muroyama R, Kato N, Yoshida H, Otsuka M, Moriyama M, Wang Y, Shao RX, Dharel N, Tanaka Y, Ohta M, Tateishi R, Shiina S, Tatsukawa M, Fukai K, Imazeki F, Yokosuka O, Shiratori Y, Omata M (December 2006). "Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma". Journal of Hepatology. 45 (6): 805–12. doi:10.1016/j.jhep.2006.07.025. PMID 17050029.
  • Chen J, Siddiqui A (June 2007). "Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress". Journal of Virology. 81 (12): 6757–60. doi:10.1128/JVI.00172-07. PMC 1900104. PMID 17428866.
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