Contents

HIST1H3I

Protein-coding gene in the species Homo sapiens

H3C11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WKJ, 3B95, 2C1J, 3AYW, 3WA9, 3U4S, 5AVB, 2CV5, 5AV5, 3U31, 2UXN, 3AZK, 2C1N, 5C11, 3QO2, 3X1V, 5C13, 4A0J, 4U68, 5AV8, 4LLB, 3U5O, 1O9S, 4FT2, 4HON, 3W99, 3ZVY, 4Z0R, 5AVC, 1CT6, 1Q3L, 3O37, 3W97, 3SOW, 3KMT, 4YM6, 4A7J, 3UEE, 2KWK, 4F4U, 3UEF, 3UIG, 4BD3, 3AZL, 4QBR, 4F56, 3AFA, 4LKA, 5CPK, 5FFV, 3V43, 5CH1, 3U5P, 3AZI, 3U5N, 3AZH, 3UIK, 4QBQ, 1U35, 4UY4, 2OT7, 5AV9, 2B2W, 3U3D, 3AZF, 3W98, 4I51, 4X3K, 4FWF, 2B2T, 2B2V, 4A0N, 2KWJ, 3WAA, 3QJ6, 5DAH, 3AZG, 3AZE, 3X1T, 3RIY, 2L75, 3A1B, 2VPG, 4QBS, 3O35, 5CPJ, 3ZG6, 4YM5, 3AZJ, 2RI7, 3AZN, 3AVR, 5CPI, 2LBM, 3W96, 3O34, 2M0O, 4L7X, 5CH2, 5AV6, 3AZM, 4UP0, 3X1S, 2OX0, 3UII, 3SOU, 4N4H, 4TN7, 1CS9, 3X1U, 4LXL, 2B2U, 2OQ6, 3RIG, 5C3I, 4YHP, 5B24, 5D6Y, 4YHZ, 4Z2M, 5HJD, 5HJC, 5HJB, 5B2I, 5HYN, 5FB0, 5FB1, 5IQL, 5B2J, 5JIN
Identifiers
Aliases	H3C11, H3.f, H3/f, H3FF, histone cluster 1, H3i, histone cluster 1 H3 family member i, H3 clustered histone 11, HIST1H3I, H3C4, H3C7, H3C12, H3C2, H3C8, H3C10, H3C3, H3C6, H3C1
External IDs	OMIM: 602814; MGI: 2448326; HomoloGene: 134496; GeneCards: H3C11; OMA:H3C11 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,871,845 bp[1] End 27,872,346 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,745,708 bp[2] End 23,746,543 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells tendon of biceps brachii epithelium of colon Achilles tendon mucosa of transverse colon ventricular zone tonsil corpus callosum ganglionic eminence granulocyte Top expressed in uterus genital tubercle embryo embryo tail of embryo yolk sac spermatocyte mesencephalon bone marrow morula More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding histone binding protein binding protein heterodimerization activity cadherin binding nucleosomal DNA binding Cellular component membrane nucleoplasm chromosome extracellular region nuclear chromosome extracellular exosome nucleosome nucleus protein-containing complex Biological process telomere organization epigenetic maintenance of chromatin in transcription-competent conformation protein heterotetramerization blood coagulation DNA replication-dependent chromatin assembly rDNA heterochromatin assembly negative regulation of gene expression, epigenetic chromatin organization regulation of gene silencing by miRNA nucleosome assembly interleukin-7-mediated signaling pathway regulation of megakaryocyte differentiation regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8354 319151 Ensembl ENSG00000275379 ENSMUSG00000069273 UniProt P68431 P84228 RefSeq (mRNA) NM_003533 NM_178205 RefSeq (protein) NP_066298 NP_003520 NP_003525 NP_003527 NP_473386 NP_835734 NP_783584 NP_835510 NP_835587 NP_038576 NP_835511 NP_835512 Location (UCSC) Chr 6: 27.87 – 27.87 Mb Chr 13: 23.75 – 23.75 Mb PubMed search [3] [4]
Wikidata
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Histone H3.1 is a protein that in humans is encoded by the HIST1H3I gene.^[5][6][7][8]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.^[8]