Jump to content

Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

(Top) 1 Function 2 Interactions 3 See also 4 References 5 Further reading

HMGN1

●Татарча / tatarça ●Українська Edit links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version Appearance From Wikipedia, the free encyclopedia

HMGN1

Identifiers

Aliases

HMGN1, HMG14, high mobility group nucleosome binding domain 1

External IDs

OMIM: 163920; MGI: 96120; HomoloGene: 3643; GeneCards: HMGN1; OMA:HMGN1 - orthologs

Gene location (Human)

Chr.	Chromosome 21 (human)^[1]

Band	21q22.2	Start	39,342,315 bp^[1]
Band	21q22.2	End	39,349,647 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16 C4\|16 56.83 cM	Start	95,921,818 bp^[2]
Band	16 C4\|16 56.83 cM	End	95,928,929 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

ganglionic eminence

endometrium

right uterine tube

appendix

lymph node

olfactory zone of nasal mucosa

rectum

islet of Langerhans

bone marrow

Top expressed in

neural layer of retina

yolk sac

ventricular zone

embryo

genital tubercle

tail of embryo

lip

zygote

right kidney

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleosomal DNA binding DNA binding chromatin binding
Cellular component	cytoplasm chromatin nucleus nucleoplasm
Biological process	positive regulation of DNA-templated transcription, elongation pyrimidine dimer repair by nucleotide-excision repair transcription-coupled nucleotide-excision repair chromatin organization regulation of transcription by RNA polymerase II response to UV-B response to UV-C regulation of development, heterochronic post-embryonic camera-type eye morphogenesis regulation of epithelial cell proliferation positive regulation of NAD+ ADP-ribosyltransferase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3150


15312

Ensembl


ENSG00000205581


ENSMUSG00000040681

UniProt


P05114


P18608

RefSeq (mRNA)


NM_004965


NM_008251

RefSeq (protein)


NP_004956


NP_032277

Location (UCSC)

Chr 21: 39.34 – 39.35 Mb

Chr 16: 95.92 – 95.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.^[5]^[6]^[7]

Function[edit]

Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation.^[8] Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.^[7]

Interactions[edit]

HMGN1 has been shown to interact with YWHAZ.^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205581 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040681 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Landsman D, Srikantha T, Westermann R, Bustin M (Dec 1986). "Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family". The Journal of Biological Chemistry. 261 (34): 16082–6. doi:10.1016/S0021-9258(18)66680-3. PMID 3782107.

^ Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M (Feb 1989). "Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family". The Journal of Biological Chemistry. 264 (6): 3421–7. doi:10.1016/S0021-9258(18)94084-6. PMID 2563381.

^ ^a ^b "Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1".

^ Martínez de Paz A, Ausió J (2016). "HMGNs: The enhancer charmers". BioEssays. 38 (3): 226–31. doi:10.1002/bies.201500157. PMID 26709929. S2CID 24768724.

^ Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins". Molecular and Cellular Biology. 22 (19): 6809–19. doi:10.1128/MCB.22.19.6809-6819.2002. PMC 134047. PMID 12215538.

Further reading[edit]

Pash J, Popescu N, Matocha M, Rapoport S, Bustin M (May 1990). "Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16". Proceedings of the National Academy of Sciences of the United States of America. 87 (10): 3836–40. Bibcode:1990PNAS...87.3836P. doi:10.1073/pnas.87.10.3836. PMC 53998. PMID 2140193.

Leffak M, Trempe JP (Jul 1985). "Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus". Nucleic Acids Research. 13 (13): 4853–69. doi:10.1093/nar/13.13.4853. PMC 321831. PMID 4022776.

Postnikov YV, Trieschmann L, Rickers A, Bustin M (Sep 1995). "Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores". Journal of Molecular Biology. 252 (4): 423–32. doi:10.1006/jmbi.1995.0508. PMID 7563062.

Ding HF, Rimsky S, Batson SC, Bustin M, Hansen U (Aug 1994). "Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14". Science. 265 (5173): 796–9. Bibcode:1994Sci...265..796D. doi:10.1126/science.8047885. PMID 8047885.

Pash JM, Alfonso PJ, Bustin M (Jun 1993). "Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation". The Journal of Biological Chemistry. 268 (18): 13632–8. doi:10.1016/S0021-9258(19)38695-8. PMID 8514795.

Bustin M, Alfonso PJ, Pash JM, Ward JM, Gearhart JD, Reeves RH (Dec 1995). "Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin". DNA and Cell Biology. 14 (12): 997–1005. doi:10.1089/dna.1995.14.997. PMID 8534374.

Hock R, Scheer U, Bustin M (Dec 1998). "Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport". The Journal of Cell Biology. 143 (6): 1427–36. doi:10.1083/jcb.143.6.1427. PMC 2132996. PMID 9852141.

Louie DF, Gloor KK, Galasinski SC, Resing KA, Ahn NG (Jan 2000). "Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry". Protein Science. 9 (1): 170–9. doi:10.1110/ps.9.1.170. PMC 2144438. PMID 10739259.

Bergel M, Herrera JE, Thatcher BJ, Prymakowska-Bosak M, Vassilev A, Nakatani Y, Martin B, Bustin M (Apr 2000). "Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes". The Journal of Biological Chemistry. 275 (15): 11514–20. doi:10.1074/jbc.275.15.11514. PMID 10753971.

Prymakowska-Bosak M, Misteli T, Herrera JE, Shirakawa H, Birger Y, Garfield S, Bustin M (Aug 2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Molecular and Cellular Biology. 21 (15): 5169–78. doi:10.1128/MCB.21.15.5169-5178.2001. PMC 87241. PMID 11438671.

Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins". Molecular and Cellular Biology. 22 (19): 6809–19. doi:10.1128/MCB.22.19.6809-6819.2002. PMC 134047. PMID 12215538.

Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS (Jun 2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". The EMBO Journal. 22 (11): 2788–97. doi:10.1093/emboj/cdg273. PMC 156769. PMID 12773393.

Zou Y, Jiang X, Wang Y (May 2004). "Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells". Biochemistry. 43 (20): 6322–9. doi:10.1021/bi0362828. PMID 15147216.

Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

This protein-related article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=HMGN1&oldid=1188170004" Categories: ●Genes on human chromosome 21 ●Protein stubs Hidden categories: ●Articles with short description ●Short description matches Wikidata ●All stub articles ●This page was last edited on 3 December 2023, at 19:35 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view