Harold Joseph Morowitz (December 4, 1927 – March 22, 2016) was an American biophysicist who studied the application of thermodynamicstoliving systems.[1][2] Author of numerous books and articles, his work includes technical monographs as well as essays.[3][4] The origin of life was his primary research interest for more than fifty years.[5] He was the Robinson Professor of Biology and Natural Philosophy at George Mason University after a long career at Yale.[6]
Morowitz was a longtime consultant for NASA, and served on the committees that planned the quarantine procedures for Apollo 11 and the biology experiments the Viking probe carried to the surface of Mars. He was a member of the science advisory committee for Biosphere 2inOracle, Arizona, which, at 3.14 acres, is the largest enclosed ecosystem ever built.[9]
Some leading biophysicists have suggested that Morowitz may have discovered a "fourth law of thermodynamics" when, in 1968, he found that, "in steady state systems, the flow of energy through the system from a source to a sink will lead to at least one cycle in the system."[10] Eric D. Schneider, for example, says, "Morowitz's cycling theorem is the best candidate for a fourth law of thermodynamics."[11]
Morowitz's book Energy Flow in Biology laid out his central thesis that "the energy that flows through a system acts to organize that system,"[12] an insight later quoted on the inside front cover of The Last Whole Earth Catalog. He was a vigorous proponent of the view that life on earth emerged deterministically from the laws of chemistry and physics,[13] and so believed it highly probable that life exists widely in the universe.[5][14] The origin of life being a very wide subject of study, his scientific work encompasses, more specifically, several related subjects such as: the origin of the chemiosmotic mechanism, the prebiotic synthesis of primitive cell membranes, the characteristics of a ‘minimal cell’ (including the minimal genome), and the origin and evolution of protometabolic networks (in a submarine, hydrothermal context).
In 1981, he testified at "McLean v. Arkansas" (nicknamed "Scopes II") that creationism has no scientific basis and so should not be taught as science in public schools.[15]
The McLean v Arkansas trial, held in the Federal District Court in Little Rock, Arkansas, dealt with “Balanced Treatment of Creation Science and Evolution Science in the Public Schools” and was of considerable interest at the time. Morowitz described his testimony on this occasion in an essay “Tell it to the Judge” published in a somewhat whimsical collection of essays entitled “Mayonnaise and the Origin of Life”.[17] Morowitz’s testimony was related to the aspect of the case dealing with abiogenesis, “the emergence of life from nonlife.” In support of creationism, the argument had been made that the second law of thermodynamics precludes that abiogenesis could have occurred by a natural process; thus there was a requirement for supernatural events. According to the second law, isolated systems move towards the maximum degree of molecular disorder (life on earth is an ordered system). Also in this case, “isolated system” means the absence of flows of both energy and matter into and out of the system.
Much of Morowitz’s scientific career had been devoted to understanding the thermodynamic foundations of biological organization. When he was called to give his expert testimony he noted that Ludwig Boltzmann, the distinguished Austrian physicist had in 1886 resolved the confusion concerning the applicability of the second law of thermodynamics to living systems. Boltzmann had made clear that the Earth, rather than being an isolated system, is an open system undergoing a flow of solar energy from the sun. Thus the surface of the Earth is not limited by a law that is restricted to isolated entities. Morowitz also pointed out that newer developments in the field of irreversible thermodynamics (see Irreversible Process and Lars Onsager), indicated that systems become ordered under a flow of energy. In his testimony Morowitz concluded that the existence of life involves no contradictions to the laws of physics.
Morowitz, H.J. (1953), “The Information Content of Living Systems”, Physical Review, 91, No. 2, pp. 492–493.
Morowitz, Harold J. and Spaulding, Marie (1958). “A statistical analysis of the order of certain amino acids in the protein of Escherichia coli”, Biochimica et Biophysica Acta, Volume 29, Issue 3 (September 1958), pp. 514–521. doi: 10.1016/0006-3002(58)90007-6
Morowitz, Harold (1966). “The Minimum Size of Cells”, pp. 446–477. In: Wolstenholme, G. E. W. and O'Connor, Maeve (Eds.), Ciba Foundation Symposium: Principles of Biomolecular Organization, Ciba Foundation, 1966. doi: 10.1002/9780470719442.ch16
Morowitz, Harold J. (1967). “Biological Self-Replicating Systems”, pp. 35–59. In: Snell, Fred M. (Ed.) Progress in Theoretical Biology, Volume 1, Academic Press, New York, 1967.
Morowitz, Harold J. (1969). “A mechanism for the amplification of fluctuations in racemic mixtures”, Journal of Theoretical Biology, Vol. 25, Issue 3 (December 1969), pp. 491–494. doi: 10.1016/S0022-5193(69)80035-4
Folsome, C. E. and Morowitz, H. J. (1969). “Prebiological membranes: Synthesis and properties”, Space Life Sciences, Vol. 1, Issue 4 (March 1969), pp. 538–544. doi: 10.1007/BF00924244
Morowitz, Harold J. (1977). “Perspectives on Thermodynamics and the Origin of Life”, Advances in Biological and Medical Physics, Vol. 16, pp. 151–163. doi: 10.1016/B978-0-12-005216-5.50013-X
Morowitz, Harold J. (1981). “Phase separation, charge separation and biogenesis”, Biosystems, Vol. 14, Issue 1, pp. 41–47. doi: 10.1016/0303-2647(81)90020-4
Smith, Temple F. and Morowitz, Harold J. (1982). “Between history and physics”, Journal of Molecular Evolution, Vol. 18, Issue 4 (July 1982), pp. 265–282. doi: 10.1007/BF01734104
Morowitz, H. J. (1984). “The completeness of molecular biology”, Israel Journal of Medical Sciences, Vol. 20, Issue 9 (September 1984), pp. 750–753.
Morowitz, Harold J. (1987). “A Hardware View of Biological Organization”, pp. 53–64. In: Yates, F. Eugene, Garfinkel, Alan, Walter, Donald O. and Yates, Gregory B. (Eds.), Self-Organizing Systems: The Emergence of Order. Springer, 1987. doi: 10.1007/978-1-4613-0883-6_4
Morowitz, Harold J., Heinz, Bettina and Deamer, David W. (1988). “The chemical logic of a minimum protocell”, Origins of Life and Evolution of the Biosphere, Vol. 18, Issue 3 (September 1988), pp. 281–87. doi: 10.1007/BF01804674
MacElroy, R.D., Morowitz, H., and Pohorille, A. (1989). “Ion transport mechanisms and prebiotic membranes”, Origins of Life and Evolution of the Biosphere, Vol. 19, Issues 3-5 (May 1989), pp. 295–296. doi: 10.1007/BF02388856
Morowitz, Harold. J. (1994). “Artificial biochemistry, life before enzymes”, pp. 381–388. In: Langton, Christopher G. (Ed.), Artificial Life III: Proceedings of the Workshop on Artificial Life, Held June 1992 in Santa Fe, New Mexico. Reading, Mass: Addison-Wesley, 1994.
Morowitz, Harold, Peterson, Eta and Chang, Sherwood (1995). “The synthesis of glutamic acid in the absence of enzymes: Implications for biogenesis”, Origins of Life and Evolution of the Biosphere, Vol. 25, Issue 4 (August 1995), pp. 395–399. doi: 10.1007/BF01581777
Morowitz, Harold J. “The Secret of Life”, Hospital Practice, Vol. 30, Issue 7 (July 1995), pp. 19–20. doi: 10.1080/21548331.1995.11443220
Morowitz, Harold J. (1999). “A theory of biochemical organization, metabolic pathways, and evolution”, Complexity, Vol. 4, Issue 6 (July/August 1999), pp. 39–53. doi: 10.1002/(SICI)1099-0526(199907/08)4:6<39::AID-CPLX8>3.0.CO;2-2
Morowitz, Harold J., Kostelnik, Jennifer D., Yang, Jeremy, and Cody, George D. (2000). “The origin of intermediary metabolism”, Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 14 (June 20, 2000), pp. 7704–7708. doi: 10.1073/pnas.110153997
Cody, G.D., Boctor, N.Z., Hazen, R.M., Brandes, J.A., Morowitz, Harold J., Yoder Jr, H.S. (2001).“Geochemical roots of autotrophic carbon fixation: hydrothermal experiments in the system citric acid, H2O-(±FeS)−(±NiS)”, Geochimica et Cosmochimica Acta, Vol. 65, Issue 20 (15 October 2001), pp. 3557–3576. doi: 10.1016/S0016-7037(01)00674-3
Morowitz, Harold (2002). “Phenetics, a born again science”, Complexity, Vol. 8, Issue 1 (September/October 2002), pp. 12–13. doi: 10.1002/cplx.10058
Morowitz, Harold (2003). “How many genes does an organism need?”, Complexity, Vol. 9, Issue 2 (November/December 2003), pp. 11–12. doi: 10.1002/cplx.20016
Smith, Eric and Morowitz, Harold J. (2004). “Universality in intermediary metabolism”, Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 36 (August 30, 2004), pp. 13168–13173. doi: 10.1073/pnas.0404922101
Morowitz, Harold J., Srinivasan, Vijayasarathy, and Smith, Eric (2004). “A Paradigm Shift in Biochemistry”, Journal of the Washington Academy of Sciences, Vol. 90, No. 3 (Autumn 2004), pp. 58–66. JSTOR: 24531013
Smith, D. Eric and Morowitz, Harold J. (2004). “Searching for the Laws of Life”, SFI bulletin, winter 2004, pp. 16–23.
Copley, Shelley D., Smith, Eric, and Morowitz, Harold J. (2005). “A mechanism for the association of amino acids with their codons and the origin of the genetic code”, Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 12 (March 11, 2005), pp. 4442–4447. doi: 10.1073/pnas.0501049102
Morowitz, Harold J., Srinivasan, Vijaysarathy, Copley, Shelley and Smith, Eric (2005). “The Simplest Enzyme Revisited: The Chicken and Egg Argument Solved”, Complexity, Vol., No. 5, pp. 12–13. doi: 10.1002/cplx.20087
Morowitz, Harold J., Broyles, Daniel and Lasus, Howard (2005). “The Robustness of Intermediary Metabolism”, pp. 154–159. In: Sapp, J. (Ed.), Microbial Phylogeny and Evolution: Concepts and Controversies, Oxford University Press, 2005.
Morowitz, Harold J., Srinivasan, Vijayasarathy and Smith, Eric (2006). “The Swiss Army Knife of Biological Catalysis: A Compact Toolkit of Organic Functional Groups”, Complexity, Vol. 11, No. 3, pp. 9–10. doi: 10.1002/cplx.20112
Copley, Shelley D., Smith, Eric and Morowitz, Harold J. (2007). “The origin of the RNA world: Co-evolution of genes and metabolism”, Bioorganic Chemistry, Vol. 35, Issue 6 (December 2007), pp. 430–443. doi: 10.1016/j.bioorg.2007.08.001
Smith, Eric and Morowitz, Harold J. (2007). “Framing the question of fine-tuning for intermediary metabolism”, pp. 384–420. In: John D. Barrow, Simon Conway Morris, Stephen J. Freeland and Charles L. Harper, Jr. (Eds.), Fitness of the Cosmos for Life: Biochemistry and Fine-Tuning, Cambridge University Press, 2007. doi: 10.1017/CBO9780511536557.020
Srinivasan, Vijayasarathy and Morowitz, Harold J. (2009). “The Canonical Network of Autotrophic Intermediary Metabolism: Minimal Metabolome of a Reductive Chemoautotroph”, Biological Bulletin, Vol. 216, No. 2 (April 2009), pp. 126–130. doi: 10.1086/BBLv216n2p126
Srinivasan, Vijayasarathy and Morowitz, Harold J. (2009). “Analysis of the Intermediary Metabolism of a Reductive Chemoautotroph”, Biological Bulletin, Vol. 217, No. 3 (December 2009), pp. 222–232. doi: 10.1086/BBLv217n3p222
Smith, Eric, Morowitz, Harold J. and Copley, Shelley D. (2008). “Core Metabolism as a Self-Organized System”, pp. 432–460. In: Steen Rasmussen, Mark A. Bedau, Liaohai Chen, David Deamer, David C. Krakauer, Norman H. Packard, and Peter F. Stadler (Eds.), Protocells: Bridging Nonliving and Living Matter, MIT Press, 2008. doi: 10.7551/mitpress/9780262182683.003.0020
Morowitz, Harold J., Srinivasan, Vijayasarathy and Smith, Eric (2009). “Revolution in Organic Chemistry and Its Implication in Biogenesis”, Complexity, Vol. 14, Issue 6 (July/August 2009), pp. 7–8. doi: 10.1002/cplx.20286
Morowitz, Harold J., Srinivasan, Vijayasarathy and Smith, Eric (2010). “Ligand Field Theory and the Origin of Life as an Emergent Feature of the Periodic Table of Elements”, Biological Bulletin, Vol. 219, No. 1 (August 2010), pp. 1–6. doi: 10.1086/BBLv219n1p1
Smith, Eric and Morowitz, Harold J. (2010). “The Autotrophic Origins Paradigm and Small-Molecule Organocatalysis”, Origins of Life and Evolution of Biospheres, Vol. 40, Issue 4–5 (October 2010), pp. 397–402. doi: 10.1007/s11084-010-9213-2
Smith, Eric and Morowitz, Harold J. (2010). “Confederacy Based on Synthetic-pathway and Bio-energetic Modularity”, Origins of Life and Evolution of Biospheres, Vol. 40, Issue 4–5 (October 2010), pp. 467–475. doi: 10.1007/s11084-010-9213-2
Srinivasan, Vijayasarathy, Morowitz, Harold J. and Huber, Harald (2012). “What is an autotroph?”, Archives of Microbiology, Vol. 194, Issue 2 (February 2012), pp. 135–140. doi: 10.1007/s00203-011-0755-0
Proceedings of the First National Biophysics Conference. Yale University Press, 1959, Morowitz, H.J. and Quastler, H., Editors.
Life and the Physical Sciences: Introduction to Biophysics. Holt, Rinehart and Winston, Inc., 1963, Morowitz, H.J.
Theoretical and Mathematical Biology. Blaisdell Publishing Co., 1965, Waterman, T. and Morowitz, H., Editors.
Energy Flow in Biology. Academic Press, 1968, Morowitz, Harold J.
Entropy for Biologists. Academic Press, 1970, Morowitz, Harold J.
Foundations of Bioenergetics. Academic Press, 1978, Morowitz, Harold J.
Models for Biomedical Research: A New Perspective. National Academy Press, 1985, Committee on Models for Biomedical Research, Harold J. Morowitz, Chairman.
Report of the Matrix of Biological Knowledge Workshop: July 13-August 14, 1987, Santa Fe Institute, 1987, Morowitz, Harold J. and Smith Temple.
The Mind, the Brain, and Complex Adaptive Systems, Addison-Wesley, 1994, Morowitz, Harold J. and Singer, Jerome L.
