| Hepatitis B virus PRE 1151–1410 | |
|---|---|
Predicted secondary structure and sequence conservation of Hepatitis B virus PRE 1151–1410
| |
| Identifiers | |
| Rfam | RF02816 |
| Other data | |
| Domain(s) | Viruses |
| GO | GO:0051168,GO:0043484 |
| SO | SO:0005836 |
| PDB structures | PDBe |
Hepatitis B virus PRE 1151–1410 (HBV post-transcriptional regulatory element, nucleotides 1151–1410) is a part of 500 base pair long HBV PRE, that has been proposed to be the hepatitis B virus (HBV) RNA export element.[1][2][3] However, the function is controversial and new regulatory elements have been predicted within PRE.[4] PRE 1151–1410 enhances nuclear export of intronless transcripts and represses the splicing mechanism to a comparable degree to that of the full-length PRE. Hence it was proposed to be the core HBV PRE element.[4] PRE1151–1410 contains 3 known regulatory elements: PRE SL-alpha (nucleotides 1292–1321),[5] human La protein binding site (nucleotide 1275–1291),[6] SRE-1 (nucleotides 1252–1348).[7]
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