Ahybrid mass spectrometer is a device for tandem mass spectrometry that consists of a combination of two or more m/z separation devices of different types.
The different m/z separation elements of a hybrid mass spectrometer can be represented by a shorthand notation. The symbol Q represents a quadrupole mass analyzer, q is a radio frequency collision quadrupole, TOF is a time-of-flight mass spectrometer, B is a magnetic sector and E is an electric sector.
Asector instrument can be combined with a collision quadrupole and quadrupole mass analyzer to form a hybrid instrument.[1] A BEqQ configuration with a magnetic sector (B), electric sector (E), collision quadrupole (q) and m/z selection quadrupole (Q) have been constructed[2][3] and an instrument with two electric sectors (BEEQ) has been described.[4]
Atriple quadrupole mass spectrometer with the final quadrupole replaced by a time-of-flight device is known as a quadrupole time-of-flight instrument.[5][6] Such an instrument can be represented as QqTOF.
In an ion trap instrument, ions are trapped in a quadrupole ion trap and then injected into the TOF. The trap can be 3-D[7] or a linear trap.[8]
A linear ion trap combined with a Fourier transform ion cyclotron resonance[9]orOrbitrap[10][11][12] mass spectrometer is marketed by Thermo Scientific as the LTQ FT and LTQ Orbitrap, respectively.
|
| |
|---|---|
| |
| Ion source |
|
| Mass analyzer |
|
| Detector |
|
| MS combination |
|
| Fragmentation |
|
| |
