Contents

IL22RA1

Protein-coding gene in the species Homo sapiens

IL22RA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DGC, 3DLQ
Identifiers
Aliases	IL22RA1, CRF2-9, IL22R, IL22R1, interleukin 22 receptor subunit alpha 1
External IDs	OMIM: 605457; MGI: 2663588; HomoloGene: 10943; GeneCards: IL22RA1; OMA:IL22RA1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 24,119,771 bp[1] End 24,143,140 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 67.99 cM Start 135,455,483 bp[2] End 135,479,451 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas jejunal mucosa skin of leg skin of abdomen skin of arm pancreatic ductal cell mucosa of ileum duodenum mucosa of colon gingival epithelium Top expressed in jejunum ileum colon duodenum lip zone of skin yolk sac esophagus liver human kidney More reference expression data BioGPS n/a
Gene ontology Molecular function interferon receptor activity protein binding interleukin-20 binding cytokine receptor activity Cellular component integral component of membrane membrane plasma membrane Biological process defense response to Gram-negative bacterium biological process cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58985 230828 Ensembl ENSG00000142677 ENSMUSG00000037157 UniProt Q8N6P7 Q80XZ4 RefSeq (mRNA) NM_021258 NM_178257 RefSeq (protein) NP_067081 NP_839988 Location (UCSC) Chr 1: 24.12 – 24.14 Mb Chr 4: 135.46 – 135.48 Mb PubMed search [3] [4]
Wikidata
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Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene.^[5]

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.