Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.[5][6]
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.[6]
ING4 has been shown to interact with EP300,[5] RELA[7] and P53.[5][8]
PDB gallery
| |
---|---|
1wen: Solution structure of PHD domain in ING1-like protein BAC25079
1weu: Solution structure of PHD domain in ING1-like protein BAC25009
2jmq:
|
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| |||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it. |