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Imiclopazine







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From Wikipedia, the free encyclopedia
  

Imiclopazine
INN: Imiclopazine
Clinical data
Trade namesPonsital[1][2]
ATC code
Legal status
Legal status
Identifiers

  • 1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methylimidazolidin-2-one

CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H32ClN5OS
Molar mass486.08 g·mol−1
3D model (JSmol)

  • CN1CCN(C1=O)CCN2CCN(CC2)CCCN3C4=CC=CC=C4SC5=C3C=C(C=C5)Cl

  • InChI=1S/C25H32ClN5OS/c1-27-11-17-30(25(27)32)18-16-29-14-12-28(13-15-29)9-4-10-31-21-5-2-3-6-23(21)33-24-8-7-20(26)19-22(24)31/h2-3,5-8,19H,4,9-18H2,1H3 checkY

  • Key:OCDYNPAUUKDNOR-UHFFFAOYSA-N checkY

Imiclopazine is an antipsychotic drug of the phenothiazines class, developed in the 1960s by the pharmaceutical company Asta-Werke under the brand name Ponsital. It demonstrated strong sedative and antiemetic properties.[4][5]

It was initially researched for the treatment of schizophrenia and had favorable clinical trials,[6] but ultimately was never brought to market.[4]

References[edit]

  1. ^ Milne GW (2002-02-01). Drugs: Synonyms and Properties (2nd ed.). John Wiley & Sons. p. 427. ISBN 978-0-566-08491-1.
  • ^ "Substâncias e remédios sob controle" [Substances and drugs under control] (PDF). Jornal do Brasil (in Brazilian Portuguese). 1986-11-05. p. 14. Archived (PDF) from the original on 2023-08-08. Retrieved 2023-08-08.
  • ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-03.
  • ^ a b "Imiclopazine". NCATS Inxight Drugs. National Center for Advancing Translational Sciences (NCATS). Retrieved 2023-08-09.
  • ^ Nurowska K, Welbel L (1973). "[Treatment of schizophrenia with imiclopazine, pimozide, imagotan and trifluorperidol. Comparative study]". Psychiatria Polska. 7 (1): 57–63. PMID 4146043.
  • ^ Eckmann F, Immich H, Schäpperle O (1968). "Langzeitbehandlung mit PONSITAL bei chronisch psychisch Kranken". International Pharmacopsychiatry (in German). 1 (1): 80–85. doi:10.1159/000467919. ISSN 0020-8272.

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Imiclopazine&oldid=1169760446"
    Categories: 
    ●Typical antipsychotics
     ●Phenothiazines
     ●Piperazines
     ●Abandoned drugs
     ●Imidazolidinones
     ●Chloroarenes
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     ●CS1 German-language sources (de)
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