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1 References  













Iodobenzamide






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From Wikipedia, the free encyclopedia
  
(Redirected from Iolopride (123I))
Iodobenzamide
Names
Preferred IUPAC name

N-{[(2S)-1-Ethylpyrrolidin-2-yl]methyl}-2-hydroxy-3-iodo-6-methoxybenzamide

Other names

IBZM; Iolopride

Identifiers

CAS Number
  • 113716-48-6 (123I) checkY
  • 113452-80-5 (125I) checkY

    • 3D model (JSmol)
    ChemSpider

    PubChem CID
    UNII
  • 5E76SOQ99K (123I) checkY
  • 0709QG1NOY (125I) checkY

    • CompTox Dashboard (EPA)

    • InChI=1S/C15H21IN2O3/c1-3-18-8-4-5-10(18)9-17-15(20)13-12(21-2)7-6-11(16)14(13)19/h6-7,10,19H,3-5,8-9H2,1-2H3,(H,17,20)/t10-/m0/s1

      Key: CANPFCFJURGKAX-JTQLQIEISA-N

    • InChI=1/C15H21IN2O3/c1-3-18-8-4-5-10(18)9-17-15(20)13-12(21-2)7-6-11(16)14(13)19/h6-7,10,19H,3-5,8-9H2,1-2H3,(H,17,20)/t10-/m0/s1

      Key: CANPFCFJURGKAX-JTQLQIEIBE

    • Ic1ccc(OC)c(c1O)C(=O)NC[C@H]2N(CC)CCC2

    Properties

    Chemical formula

    		 C15H21IN2O3
    Molar mass 404.248 g·mol−1
    Pharmacology

    ATC code

    		 V09AB02 (WHO)

    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    Infobox references

    Iodobenzamide (IBZMoriolopride) is a pharmaceutical drug used for diagnostic purposes. It is a dopamine antagonist and it can be used by nuclear medicine physicians as a radioactive tracer for SPECT where the radioactive isotopeisiodine-123oriodine-125.[1][2] The main purpose of a brain study with IBZM is the differentiation of Parkinson's disease from other neurodegenerative diseases such as Lewy Body dementia and multiple system atrophy.

    References[edit]

    1. ^ Kung, H. F.; Guo, Y. Z.; Billings, J.; Xu, X.; Mach, R. H.; Blau, M.; Ackerhalt, R. E. (1988). "Preparation and biodistribution of [125I]IBZM: a potential CNS D-2 dopamine receptor imaging agent". Nuclear Medicine and Biology. 15 (2): 195–201. doi:10.1016/0883-2897(88)90088-8. PMID 2966782.
  • ^ Kung, Hank, F.; Alavi; Chang; Kung; Keyes; Velchik; Billings; Pan; Noto (1990). "In vivo SPECT imaging of CNS D-2 dopamine receptors: initial studies with iodine-123-IBZM in humans". Journal of Nuclear Medicine. 31 (5): 573–579. PMID 2140408.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Iodobenzamide&oldid=1203340517"
    Categories: 
    ●Radiopharmaceuticals
     ●Benzamides
     ●Iodobenzene derivatives
     ●Phenols
     ●Pharmacology stubs
     ●Nuclear medicine stubs
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