Contents

JARID1B

Protein-coding gene in the species Homo sapiens

KDM5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MA5, 2MNY, 2MNZ, 5A1F, 5A3N, 5A3P, 5A3T, 5A3W, 5FPL, 5FPU, 5FV3, 5FZ6, 5FUP, 5FUN, 5FZK, 5FYZ, 5FZ7, 5FZ9, 5FYU, 5FZB, 5FZC, 5FYT, 5FZ0, 5FYY, 5FZ1, 5FZ3, 5FZL, 5FZA, 5FZ4
Identifiers
Aliases	KDM5B, CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1, lysine demethylase 5B, MRT65
External IDs	OMIM: 605393; MGI: 1922855; HomoloGene: 48448; GeneCards: KDM5B; OMA:KDM5B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 202,724,495 bp[1] End 202,808,487 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 58.24 cM Start 134,487,909 bp[2] End 134,563,023 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis ganglionic eminence ventricular zone epithelium of colon testicle gonad skin of thigh cartilage tissue Top expressed in Rostral migratory stream spermatocyte maxillary prominence mandibular prominence spermatid molar internal carotid artery ganglionic eminence abdominal wall Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription corepressor activity DNA-binding transcription factor activity dioxygenase activity metal ion binding protein binding oxidoreductase activity histone demethylase activity histone H3-tri/di/monomethyl-lysine-4 demethylase activity sequence-specific double-stranded DNA binding histone H3-methyl-lysine-4 demethylase activity histone binding zinc ion binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding methylated histone binding Cellular component nucleoplasm nucleus cytosol histone methyltransferase complex Biological process response to fungicide positive regulation of mammary gland epithelial cell proliferation regulation of transcription, DNA-templated branching involved in mammary gland duct morphogenesis uterus morphogenesis rhythmic process regulation of estradiol secretion post-embryonic development cellular response to fibroblast growth factor stimulus transcription, DNA-templated single fertilization mammary duct terminal end bud growth positive regulation of gene expression lens fiber cell differentiation negative regulation of transcription, DNA-templated histone H3-K4 demethylation, trimethyl-H3-K4-specific regulation of transcription by RNA polymerase II histone H3-K4 demethylation cellular response to leukemia inhibitory factor chromatin organization negative regulation of transcription by RNA polymerase II chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10765 75605 Ensembl ENSG00000117139 ENSMUSG00000042207 UniProt Q9UGL1 Q80Y84 RefSeq (mRNA) NM_001314042 NM_006618 NM_001347591 NM_001399817 NM_152895 RefSeq (protein) NP_001300971 NP_001334520 NP_006609 NP_690855 Location (UCSC) Chr 1: 202.72 – 202.81 Mb Chr 1: 134.49 – 134.56 Mb PubMed search [3] [4]
Wikidata
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Lysine-specific demethylase 5B also known as histone demethylase JARID1B is a demethylase enzyme that in humans is encoded by the KDM5B gene.^[5][6][7] JARID1B belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

Jarid1B (also known as KDM5B or PLU1) is in the family of JHDM genes. These are responsible for demethylation of tri- and di-methylated lysines in the 4 position of histone 3 (H3K4me3 and H3K4me2). Jarid1B is a multidomain enzyme that is part of the subfamily KDM5. The whole Jarid1 family is a protein family that possesses H3K4 histone demethylase activity.^[8]

Jarid1B has been implicated in the development of prostate, breast, and skin cancer and also has been associated with melanoma maintenance. Knockout mice (Jarid1b−/−) produced are viable in neonatal life. These mice do exhibit the phenotype of premature mortality, decreased fertility in female mice, reduction in body weight and impairment in mammary gland development. It also acted to decrease serum estrogen levels and caused reduced mammary epithelial cell proliferation in the early stages of puberty. These Jarid1b−/− mice seem to be greatly affected in many regulators of the development of mammy development such as FOXA1 and estrogen receptor α.^[9] However, others have shown that a Jarid1B knockout embryos usually have neonatal lethality due to the failure of their respiratory system. Knockout embryos have also been seen to have several different neural defects including: disorganized cranial nerves, increased incidences of exencephaly, and defects in eye development.^[10]

JARID1B has been shown to interact with FOXG1^[11] and PAX9.^[11]

• JARID1B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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