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Clinical data | |
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Other names | 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine |
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ECHA InfoCard | 100.164.683 ![]() |
Chemical and physical data | |
Formula | C14H16ClN3O |
Molar mass | 277.75 g·mol−1 |
3D model (JSmol) | |
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JNJ-7777120 was a drug being developed by Johnson & Johnson Pharmaceutical Research & Development which acts as a potent and selective antagonist at the histamine H4 receptor.[1] It has anti-inflammatory effects,[2] and has been demonstrated to be superior to traditional (H1) antihistamines in the treatment of pruritus (itching).[3] The drug was abandoned because of its short in vivo half-life and hypoadrenocorticism toxicity in rats and dogs, that prevented advancing it into clinical studies.[4]
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Simple piperazines (no additional rings) |
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Phenylpiperazines |
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Benzylpiperazines |
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Diphenylalkylpiperazines (benzhydrylalkylpiperazines) |
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Pyrimidinylpiperazines |
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Pyridinylpiperazines |
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Benzo(iso)thiazolylpiperazines |
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Tricyclics (piperazine attached via side chain) |
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Others/Uncategorized |
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