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1 See also  




2 References  













JWH-198






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From Wikipedia, the free encyclopedia
  

JWH-198
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
  • UK: Class B
  • US: Schedule I
    • Identifiers

    • (1-(2-Morpholin-4-ylethyl)indol-3-yl)-4-methoxynaphthalen-1-ylmethanone

    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    FormulaC26H26N2O3
    Molar mass414.505 g·mol−1
    3D model (JSmol)

    • C4COCCN4CCn2cc(c5ccccc25)C(=O)c3c1ccccc1c(OC)cc3

    • InChI=1S/C26H26N2O3/c1-30-25-11-10-22(19-6-2-3-8-21(19)25)26(29)23-18-28(24-9-5-4-7-20(23)24)13-12-27-14-16-31-17-15-27/h2-11,18H,12-17H2,1H3 ☒N

    • Key:QWHSUXWDDKWTOG-UHFFFAOYSA-N ☒N

     ☒NcheckY (what is this?)  (verify)

    JWH-198 is a drug from the aminoalkylindole and naphthoylindole families which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-198 has a binding affinity at the CB1 receptor of 10 nM, binding around four times more tightly than the parent compound JWH-200, which has no substitution on the naphthoyl ring.[1] It has been used mainly in molecular modelling of the cannabinoid receptors.[2][3]

    In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-198 are Schedule I Controlled Substances.[4]

    See also[edit]

    References[edit]

    1. ^ Huffman JW, Padgett LW (2005). "Recent developments in the medicinal chemistry of cannabimimetic indoles, pyrroles and indenes". Current Medicinal Chemistry. 12 (12): 1395–411. doi:10.2174/0929867054020864. PMID 15974991.
  • ^ Eissenstat MA, Bell MR, D'Ambra TE, Alexander EJ, Daum SJ, Ackerman JH, Gruett MD, Kumar V, Estep KG, Olefirowicz EM (Aug 1995). "Aminoalkylindoles: structure-activity relationships of novel cannabinoid mimetics". Journal of Medicinal Chemistry. 38 (16): 3094–105. doi:10.1021/jm00016a013. PMID 7636873.
  • ^ Shim JY, Collantes ER, Welsh WJ, Subramaniam B, Howlett AC, Eissenstat MA, Ward SJ (Nov 1998). "Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis". Journal of Medicinal Chemistry. 41 (23): 4521–32. doi:10.1021/jm980305c. PMID 9804691.
  • ^ 21 U.S.C. § 812: Schedules of controlled substances
    • Stub icon

    This cannabinoid related article is a stub. You can help Wikipedia by expanding it.

  • t
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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=JWH-198&oldid=1164683136"
    Categories: 
    ●JWH cannabinoids
     ●Aminoalkylindoles
     ●Naphthoylindoles
     ●4-Morpholinyl compounds
     ●Designer drugs
     ●CB1 receptor agonists
     ●Cannabinoid stubs
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    ●This page was last edited on 10 July 2023, at 13:18 (UTC).
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