Janet S Butel is the Chairman and Distinguished Service Professor in the molecular virology and microbiology department at Baylor College of Medicine. Her area of expertise is on polyomavirus pathogenesis of infections and disease. She has more than 120 publications on PubMed. She also has 6 publications in Nature, which is considered one of the most prestigious science journals. She is a member of 9 different organizations and has 13 honors and awards.[1]
Butel has studied polyomavirusSV40 infection in humans and animals for most of her career. She has published studies on the mechanism of SV40 entry into human cells, the role of SV40incancer and SV40genetics. In addition, Butel published an article in 2014 on the use of microRNA and SV40ingolden hamsters.[2] The golden hamster is the animal model that SV40 has been studied in and has provided evidence of its pathogenesisintumor forming cancer.[3] The animal model has been used to research the development of this virus in humans, but can not conclude any definitive pathogenesisofSV40 in humans.[4] Thus there is controversy over the exact impact of SV40 on human health. Butel's research indicates that SV40 may play a role in some human cancers, such as brain tumors and non-Hodgkin lymphoma.[5][6][7][8][9]
Dr. Butel has also studied the role of the polio vaccine and in human SV40 infection and integration of SV40 into our DNA. It was found that some vaccines contained pieces of SV40 genes. It is suspected that by incorporating SV40 into the vaccine allowed it to enter into our own DNA.[19] Butel has published studies on topics other than SV40. She has studied the immunology of women going into spaceflight, specifically cytokines and antibodies.[20] Butel also researched hepatitis B and the role it plays in DNA repair.[21][22] Dr. Butel has also contributed to higher education and is a coauthor of a medical microbiology textbook that has been used for over 50 years and in medical colleges around the world.[23] Dr. Butel has over 120 publications with over 10,000 citations, according to Google scholar.
^Vilchez, RA; Kozinetz, CA; Arrington, AS; Madden, CR; Butel, JS (1 June 2003). "Simian virus 40 in human cancers". The American Journal of Medicine. 114 (8): 675–84. doi:10.1016/s0002-9343(03)00087-1. PMID12798456.
^Butel, JS; Jafar, S; Stewart, AR; Lednicky, JA (1998). "Detection of authentic SV40 DNA sequences in human brain and bone tumours". Developments in Biological Standardization. 94: 23–32. PMID9776222.
^Maxwell, SA; Ames, SK; Sawai, ET; Decker, GL; Cook, RG; Butel, JS (February 1991). "Simian virus 40 large T antigen and p53 are microtubule-associated proteins in transformed cells". Cell Growth & Differentiation. 2 (2): 115–27. PMID1648952.
^Scorsone, KA; Zhou, YZ; Butel, JS; Slagle, BL (15 March 1992). "p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China". Cancer Research. 52 (6): 1635–8. PMID1311638.
^Donehower, LA; Harvey, M; Slagle, BL; McArthur, MJ; Montgomery CA, Jr; Butel, JS; Bradley, A (19 March 1992). "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours". Nature. 356 (6366): 215–21. Bibcode:1992Natur.356..215D. doi:10.1038/356215a0. PMID1552940. S2CID4348340.
^Ozbun, MA; Jerry, DJ; Kittrell, FS; Medina, D; Butel, JS (1 April 1993). "p53 mutations selected in vivo when mouse mammary epithelial cells form hyperplastic outgrowths are not necessary for establishment of mammary cell lines in vitro". Cancer Research. 53 (7): 1646–52. PMID8453637.
^Jerry, DJ; Ozbun, MA; Kittrell, FS; Lane, DP; Medina, D; Butel, JS (15 July 1993). "Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development". Cancer Research. 53 (14): 3374–81. PMID8324748.
^Ozbun, MA; Medina, D; Butel, JS (October 1993). "p53 mutations in mouse mammary epithelial cells: instability in culture and discordant selection of mutations in vitro versus in vivo". Cell Growth & Differentiation. 4 (10): 811–9. PMID8274450.
^Harvey, M; McArthur, MJ; Montgomery CA, Jr; Butel, JS; Bradley, A; Donehower, LA (November 1993). "Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice". Nature Genetics. 5 (3): 225–9. doi:10.1038/ng1193-225. PMID8275085. S2CID26741712.
