Jonathan L. Halperin (born January 29, 1949) is an American cardiologist and the author of Bypass (ISBN0-89586-509-2), among the most comprehensive works on the subject of coronary artery bypass surgery.[1] In addition, he is the Robert and Harriet Heilbrunn Professor of Medicine at The Mount Sinai School of Medicine as well as Director of Clinical Cardiology in the Zena and Michael A. Wierner Cardiovascular Institute at The Mount Sinai Medical Center, both in New York City.[2][3] Halperin was the principal cardiologist responsible for both the design and execution of the multi-center Stroke Prevention in Atrial Fibrillation (SPAF) clinical trials, funded by the National Institutes of Health, which helped develop antithrombotic strategies to prevent stroke, and he subsequently directed the SPORTIF clinical trials, which evaluated the first oral direct thrombin inhibitor for prevention of stroke in patients with atrial fibrillation.[2][4][5]
Halperin is the author of 3 books, 80 original peer reviewed reports, 38 chapters, 24 guidelines and position statements, 51 invited articles and 58 abstracts. He is listed among New York Magazine’s Best Doctors of 2009.[6]
Halperin was born in 1949 in Boston, Massachusetts. He earned his A.B. from Columbia University in 1971 and his M.D. from Boston University in 1975. He completed an internship in medicine (in 1976) and a residency in internal medicine (in 1977), both at University Hospital, Boston. He was a clinical and research fellow in peripheral vascular disease at the Evans Memorial Foundation for Clinical Research in Boston (1977–1978) and a fellow in cardiology at Boston City Hospital (1978–1980). He served academic appointments at Boston City Hospital, St. Elizabeth's HospitalinBrighton, Massachusetts, Boston University School of Medicine and the American Heart Association. In 1980, Halperin was appointed to The Mount Sinai School of Medicine as an Assistant Professor of Medicine. In 1993, he was named the Robert and Harriet Heilbrunn Professor of Medicine.
Halperin is a fellow of the American College of Cardiology, the American Heart Association, and the Councils on Circulation, Stroke and Cardiology of the American Heart Association. He is past president of the Society for Vascular Medicine.[7]
Halperin JL, Levine R: BYPASS: A Cardiologist Reveals What Every Patient Needs To Know. New York: Times Books – Random House, 1985 ISBN0-8129-1157-1; Phoenix: The Body Press – HP Books, 1987 ISBN0-89586-509-2
Gross PA, Halperin JL, Lipkin M, Marks JH, Rivlin RS, Wise TN, Grzelka C: Managing Your Health: Strategies for Lifelong Good Health. Yonkers, NY: Consumer Reports Books, 1991. ISBN0-89043-438-7
Connolly SJ, Gore JL, Halperin JL. Aligning Clinical Practice with Evidence for Prevention of Thromboembolism in Atrial Fibrillation. Institute for Continuing Healthcare Education, 2002.
Hart, RG; Halperin, JL (September 2009). "Do current guidelines result in overuse of warfarin anticoagulation in patients with atrial fibrillation?". Annals of Internal Medicine. 151 (5): 355–6. doi:10.7326/0003-4819-151-5-200909010-00012. PMID19721024. S2CID19541531.
Ip, John; Waldo, Albert L.; Lip, Gregory Y.H.; Rothwell, Peter M.; Martin, David T.; Bersohn, Malcolm M.; Choucair, Wassim K.; Akar, Joseph G.; et al. (September 2009). "Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: Rationale, design, and clinical characteristics of the initially enrolled cohort The IMPACT study". American Heart Journal. 158 (3): 364–370.e1. doi:10.1016/j.ahj.2009.07.002. PMID19699858.
Rubboli, A; Halperin, JL (November 2008). "Pro: 'Antithrombotic therapy with warfarin, aspirin and clopidogrel is the recommended regime in anticoagulated patients who present with an acute coronary syndrome and/or undergo percutaneous coronary interventions'". Thrombosis and Haemostasis. 100 (5): 752–3. doi:10.1160/th08-05-0334. PMID18989515. S2CID19333201.
Singer, D. E.; Albers, G. W.; Dalen, J. E.; Fang, M. C.; Go, A. S.; Halperin, J. L.; Lip, G. Y. H.; Manning, W. J.; American College of Chest Physicians (June 2008). "Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)". Chest. 133 (6 Suppl): 546S–592S. doi:10.1378/chest.08-0678. PMID18574273. S2CID26716327.
Sealove, B; Aledort, L; Stacy, C; Halperin, J (2008). "Recurrent orthostatic global amnesia in a patient with postoperative hyperfibrinogenemia". Journal of Stroke and Cerebrovascular Diseases. 17 (4): 241–3. doi:10.1016/j.jstrokecerebrovasdis.2008.01.012. PMID18589346.
Chaudhari PR; Abergel J; Warner RR; Zacks J; Love BA; Halperin JL; Adler E (August 2007). "Percutaneous closure of a patent foramen ovale in left-sided carcinoid heart disease". Nat Clin Pract Cardiovasc Med. 4 (8): 455–9. doi:10.1038/ncpcardio0944. PMID17653118. S2CID5574038.
Halperin, Jonathan L (August 2008). "Thrombocytopenia during heparin therapy: a clinical conundrum". Nature Clinical Practice Cardiovascular Medicine. 5 (8): 440–1. doi:10.1038/ncpcardio1254. PMID18560407. S2CID32335541.
TheHeart.orgArchived 2009-06-12 at the Wayback Machine Kowey PR, Halperin JL, Yusuf S. Trial Design for Anticoagulation in Atrial Fibrillation Patients. American College of Cardiology Annual Scientific Sessions, March 30, 2009
New York Daily News A Mount Sinai cardiologist makes sure your heart's in the right place. By Katie Charles, February 13, 2008
