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Judith Ann Potashkin is an American professor at Rosalind Franklin University of Medicine and Science . She is best known for her research on diseases such as Parkinson's and Alzheimer's. She is an elected fellow of the American Association for the Advancement of Science .
Education and career [ edit ]
Potashkin has an undergraduate degree from Lehigh University (1977), and an M.S. in from Pennsylvania State University where she worked on the connection between ribosomal RNA synthesis and viruses.[1] In 1985, Potashkin earned her Ph.D. from the State University of New York at Buffalo working on residual nuclei in yeast.[2] Following her Ph.D. she was a postdoctoral scientist at Cold Spring Harbor Laboratory . She moved to Chicago Medical School in 1990 where she is a tenured professor.[3]
Research [ edit ]
Potashkin is known for her research on the role of RNA in neurodegenerative diseases. Her early research examined residual nuclei in Saccharomyces cerevisiae .[4] She went on to examine the genes involved in RNA splicing [5] and identified defects in RNA processing.[6] Her research on Parkinson's disease includes defining biomarkers,[7] [8] [9] characterizing dysregulated pathways,[10] and assessing the role of nutrition.[11] Her research also extends into investigations of Alzheimer's disease.[12]
Selected publications [ edit ]
Santiago, Jose A.; Potashkin, Judith A. (2013). "Shared dysregulated pathways lead to Parkinson's disease and diabetes" . Trends in Molecular Medicine . 19 (3 ): 176–186. doi :10.1016/j.molmed.2013.01.002 . PMID 23375873 .
Seidl, Stacey E.; Santiago, Jose A.; Bilyk, Hope; Potashkin, Judith A. (2014-03-07). "The emerging role of nutrition in Parkinson's disease" . Frontiers in Aging Neuroscience . 6 : 36. doi :10.3389/fnagi.2014.00036 . ISSN 1663-4365 . PMC 3945400 . PMID 24639650 .
Santiago, Jose A.; Potashkin, Judith A. (2015-02-17). "Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease" . Proceedings of the National Academy of Sciences . 112 (7 ): 2257–2262. Bibcode :2015PNAS..112.2257S . doi :10.1073/pnas.1423573112 . ISSN 0027-8424 . PMC 4343174 . PMID 25646437 .
Santiago, Jose A.; Littlefield, Alyssa M.; Potashkin, Judith A. (2016). "Integrative transcriptomic meta-analysis of Parkinson's disease and depression identifies NAMPT as a potential blood biomarker for de novo Parkinson's disease" . Scientific Reports . 6 (1 ): 34579. Bibcode :2016NatSR...634579S . doi :10.1038/srep34579 . ISSN 2045-2322 . PMC 5041099 . PMID 27680512 .
Awards and honors [ edit ]
Potashkin was elected a fellow of the American Association for the Advancement of Science in 2020.[13]
References [ edit ]
^ "Judith A. Potashkin, PhD" . Rosalind Franklin University . Retrieved 2021-11-04 .
^ Potashkin, Judith A.; Huberman, Joel A. (1986-07-01). "Characterization of DNA sequences associated with residual nuclei of Saccharomyces cerevisiae" . Experimental Cell Research . 165 (1 ): 29–40. doi :10.1016/0014-4827(86 )90530-6 . ISSN 0014-4827 . PMID 3519258 .
^ Potashkin, Judith; Naik, Karuna; Wentz-Hunter, Kelly (1993-10-22). "U2AF Homolog Required for Splicing in Vivo" . Science . 262 (5133): 573–575. Bibcode :1993Sci...262..573P . doi :10.1126/science.8211184 . PMID 8211184 .
^ Potashkin, J.; Frendewey, D. (1990-02-01). "A mutation in a single gene of Schizosaccharomyces pombe affects the expression of several snRNAs and causes defects in RNA processing" . The EMBO Journal . 9 (2 ): 525–534. doi :10.1002/j.1460-2075.1990.tb08139.x . ISSN 0261-4189 . PMC 551696 . PMID 2406130 .
^ Chen-Plotkin, Alice S.; Albin, Roger; Alcalay, Roy; Babcock, Debra; Bajaj, Vikram; Bowman, Dubois; Buko, Alex; Cedarbaum, Jesse; Chelsky, Daniel; Cookson, Mark R.; Dawson, Ted M. (2018-08-15). "Finding useful biomarkers for Parkinson's disease" . Science Translational Medicine . 10 (454): eaam6003. doi :10.1126/scitranslmed.aam6003 . PMC 6097233 . PMID 30111645 .
^ Santiago, Jose A.; Potashkin, Judith A. (2015-02-17). "Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease" . Proceedings of the National Academy of Sciences . 112 (7 ): 2257–2262. Bibcode :2015PNAS..112.2257S . doi :10.1073/pnas.1423573112 . ISSN 0027-8424 . PMC 4343174 . PMID 25646437 .
^ Potashkin, Judith A.; Santiago, Jose A.; Ravina, Bernard M.; Watts, Arthur; Leontovich, Alexey A. (2012-08-27). "Biosignatures for Parkinson's Disease and Atypical Parkinsonian Disorders Patients" . PLOS ONE . 7 (8 ): e43595. Bibcode :2012PLoSO...743595P . doi :10.1371/journal.pone.0043595 . ISSN 1932-6203 . PMC 3428307 . PMID 22952715 .
^ Santiago, Jose A.; Potashkin, Judith A. (2013). "Shared dysregulated pathways lead to Parkinson's disease and diabetes" . Trends in Molecular Medicine . 19 (3 ): 176–186. doi :10.1016/j.molmed.2013.01.002 . PMID 23375873 .
^ Seidl, Stacey; Santiago, Jose; Bilyk, Hope; Potashkin, Judith (2014). "The emerging role of nutrition in Parkinson's disease" . Frontiers in Aging Neuroscience . 6 : 36. doi :10.3389/fnagi.2014.00036 . ISSN 1663-4365 . PMC 3945400 . PMID 24639650 .
^ Santiago, Jose A.; Potashkin, Judith A. (2021-02-12). "The Impact of Disease Comorbidities in Alzheimer's Disease" . Frontiers in Aging Neuroscience . 13 : 631770. doi :10.3389/fnagi.2021.631770 . ISSN 1663-4365 . PMC 7906983 . PMID 33643025 .
^ "Judith Potashkin, PhD, Elected AAAS Fellow" . Rosalind Franklin University . December 17, 2020. Retrieved 2021-11-04 .
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Judith_Potashkin&oldid=1177320376 "
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