Contents

KCNS3

Protein-coding gene in the species Homo sapiens

KCNS3
Identifiers
Aliases	KCNS3, KV9.3, potassium voltage-gated channel modifier subfamily S member 3
External IDs	OMIM: 603888; MGI: 1098804; HomoloGene: 20518; GeneCards: KCNS3; OMA:KCNS3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.2 Start 17,877,847 bp[1] End 18,361,616 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.1|12 5.58 cM Start 11,140,203 bp[2] End 11,201,057 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vastus lateralis muscle Skeletal muscle tissue of rectus abdominis visceral pleura Skeletal muscle tissue of biceps brachii retinal pigment epithelium hair follicle muscle of thigh palpebral conjunctiva gastrocnemius muscle upper lobe of left lung Top expressed in lumbar spinal ganglion morula olfactory epithelium embryo embryo blastocyst primary visual cortex dentate gyrus of hippocampal formation granule cell white adipose tissue superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity ion channel activity potassium channel regulator activity voltage-gated potassium channel activity Cellular component integral component of membrane Golgi apparatus membrane voltage-gated potassium channel complex plasma membrane cytosol Biological process regulation of insulin secretion regulation of ion transmembrane transport ion transport potassium ion transport transmembrane transport potassium ion transmembrane transport protein homooligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3790 238076 Ensembl ENSG00000170745 ENSMUSG00000043673 UniProt Q9BQ31 Q8BQZ8 RefSeq (mRNA) NM_001282428 NM_002252 NM_001168564 NM_173417 RefSeq (protein) NP_001269357 NP_002243 NP_001162036 NP_775593 Location (UCSC) Chr 2: 17.88 – 18.36 Mb Chr 12: 11.14 – 11.2 Mb PubMed search [3] [4]
Wikidata
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Potassium voltage-gated channel subfamily S member 3 (Kv9.3) is a protein that in humans is encoded by the KCNS3 gene.^[5][6][7] KCNS3 gene belongs to the S subfamily of the potassium channel family.^[7] It is highly expressed in pulmonary artery myocytes,^[8][9][10] placenta,^[11] and parvalbumin-containing GABA neuronsinbrain cortex.^[12][13] In humans, single-nucleotide polymorphisms of the KCNS3 gene are associated with airway hyperresponsiveness,^[14] whereas decreased KCNS3 mRNA expression is found in the prefrontal cortex of patients with schizophrenia.^[13]

Function[edit]

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The Kv9.3 protein (encoded by KCNS3 gene) is not functional by itself^[9] but can form functional heteromultimers with Kv2.1 (encoded by KCNB1) and Kv2.2 (encoded by KCNB2) (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins.^[8] Heteromeric Kv2.1/Kv9.3 channels form with fixed stoichiometry consisting of three Kv2.1 subunits and one Kv9.3 subunit.^[15]

See also[edit]

• Voltage-gated potassium channel

References[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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