KIAA0895 is a protein that in Homo sapiens is encoded by the KIAA0895 gene. The gene encodes a protein commonly known as the KIAA0895 protein. Its aliases include hypothetical protein LOC23366, OTTHUMP00000206979, OTTHUMP00000206980, 9530077C05Rik, and 1110003N12Rik.[5] It is located at 7p14.2.[6]
The charge distribution analysis shows that there are no negative or mixed charge clusters.[12] However, there is one positive charge cluster from amino acids 12 to 36.[12]
LOC23366 contains a protein domain of unknown function called DUF1704.[13] It also contains a region of low complexity from position 120 to position 150 in the protein,[14] and an arginine-rich area from position 12 to position 51.[15]
Using ElDorado by Genomatrix, a promoter region sequence was found.[16] The most likely promoter for KIAA0895 starts at 36389926 and goes to 36391149, with a length of 1224.[16]
KIAA0895 is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout its structure.[17] Phosphorylation at these sites is a form of gene regulation. Phosphorylation results in a conformational change in the structure of many enzymes and receptors. This causes them to become activated or deactivated.
Using a database called Mfold, a stem-loop formation for the 5' UTR region shows that there is a lack of conservation, meaning there is some precedence that these stems and loops are not used for translation regulation.[18] The ΔG value was -12.90 kcal/mol with three loops.[18] Using the same database, a stem-loop formation for the 3' UTR region shows that there is conservation, meaning there is some precedence that they are used for translation regulation.[18] The ΔG value was -636.80 kcal/mol.[18]
There are three proteins likely to be interacting proteins with KIAA0895. These proteins are ELAVL1,[20] vata,[21] and glym.[21] These interactions have experimental evidence from the sources provided.
Using three different databases, three different interacting proteins were found. These include ELAVL1, VATA, and GLYM.[21] There was experimental evidence for all three of these interacting proteins.
KIAA0895 has over 228 orthologs.[6] Orthologs have been found in mammals and eukaryotes.[23] There are homologs in 9 species.[6] The full list of organisms in which homologs have been found is given below.
