KLK4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | KLK4, AI2A1, ARM1, EMSP, EMSP1, KLK-L1, PRSS17, PSTS, kallikrein, kallikrein related peptidase 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603767; MGI: 1861379; HomoloGene: 55856; GeneCards: KLK4; OMA:KLK4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.[5][6][7]
Kallikreins are a subgroup of serine proteases having diverse physiological functions.[8] Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In particular, they may serve as biomarkers for both prostate cancer and breast cancer.
This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins.[9] Alternate splice variants for this gene have been described, but their biological validity has not been determined.[10]
PDB gallery
| |
---|---|
2bdg: Human Kallikrein 4 complex with nickel and p-aminobenzamidine
2bdh: Human Kallikrein 4 complex with zinc and p-aminobenzamidine
2bdi: Human Kallikrein 4 complex with cobalt and p-aminobenzamidine
|